Woo E, Huang C Y, Chan V, Chan Y W, Yu Y L, Chan T K
Department of Medicine, University of Hong Kong, Queen Mary Hospital.
J Neurol Neurosurg Psychiatry. 1988 Apr;51(4):557-62. doi: 10.1136/jnnp.51.4.557.
Plasma beta-thromboglobulin (BTG) was significantly elevated in the acute phase of 116 atherosclerotic thrombotic (p less than 0.0001) and 36 cardioembolic (p less than 0.005) infarcts but normal for 96 lacunes compared with controls. This elevation persisted into the 6th week after the acute event. Among atherosclerotic thrombotic infarcts, the acute beta-thromboglobulin level showed a tendency to correlate with infarct size on CT and predicted mortality at 6 weeks. These results suggest that platelet aggregation plays a primary role in the pathogenesis of atherothrombosis.
在116例动脉粥样硬化血栓形成性梗死（p<0.0001）和36例心源性栓塞性梗死（p<0.005）的急性期，血浆β-血小板球蛋白（BTG）显著升高，但与对照组相比，96例腔隙性梗死患者的血浆β-血小板球蛋白水平正常。这种升高在急性事件后持续到第6周。在动脉粥样硬化血栓形成性梗死中，急性β-血小板球蛋白水平显示出与CT上梗死灶大小相关的趋势，并可预测6周时的死亡率。这些结果表明，血小板聚集在动脉粥样硬化血栓形成的发病机制中起主要作用。
