Centre International de Recherche en Infectiologie, Inserm U1111, Université Lyon 1, Ecole Normale Supérieure de Lyon, CNRS UMR 5308, Lyon, France.
Centre National de Référence des Staphylocoques, Institut des Agent Infectieux, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Lyon, France.
Appl Environ Microbiol. 2018 May 31;84(12). doi: 10.1128/AEM.00351-18. Print 2018 Jun 15.
Fifteen currently marketed intravaginal protection products (11 types of tampon and 4 types of menstrual cup) were tested by the modified tampon sac method to determine their effect on growth and toxic shock syndrome toxin 1 (TSST-1) production. Most tampons reduced growth and TSST-1 production, with differences based on brand and composition, and the level of growth was higher in destructured than in unaltered tampons. We observed higher levels of growth and toxin production in menstrual cups than in tampons, potentially due to the additional air introduced into the bag by cups, with differences based on cup composition and size. Menstrual toxic shock syndrome is a rare but severe disease. It occurs in healthy women vaginally colonized by producing toxic shock syndrome toxin 1 using intravaginal protection, such as tampons or menstrual cups. Intravaginal protection induces TSS by the collection of catamenial products, which act as a growth medium for Previous studies evaluated the impact of tampon composition on producing toxic shock syndrome toxin 1, but they are not recent and did not include menstrual cups. This study demonstrates that highly reproducible results for growth and TSST-1 production can be obtained by using a simple protocol that reproduces the physiological conditions of tampon and cup usage as closely as possible, providing recommendations for tampon or cup use to both manufacturers and consumers. Notably, our results do not show that menstrual cups are safer than tampons and suggest that they require similar precautions.
15 种市售的阴道保护产品（11 种卫生棉条和 4 种月经杯）采用改良的卫生棉条袋法进行测试，以确定其对生长和毒性休克综合征毒素 1（TSST-1）产生的影响。大多数卫生棉条都能减少生长和 TSST-1 的产生，这取决于品牌和成分的不同，而且结构破坏的卫生棉条比未改变的卫生棉条生长水平更高。我们观察到月经杯比卫生棉条能产生更高水平的生长和毒素，这可能是由于杯子会将额外的空气引入袋中，这取决于杯子的成分和大小的不同。月经毒性休克综合征是一种罕见但严重的疾病。它发生在阴道定植的健康女性中，这些女性使用阴道保护用品，如卫生棉条或月经杯，产生毒性休克综合征毒素 1。阴道保护用品通过收集月经产物来引发 TSS，这些产物充当的生长培养基。先前的研究评估了卫生棉条成分对产生毒性休克综合征毒素 1 的影响，但它们不是最新的，也没有包括月经杯。本研究表明，通过使用一种简单的方案，可以获得高度可重复的生长和 TSST-1 产生结果，该方案尽可能地模拟了卫生棉条和杯子使用的生理条件，为制造商和消费者提供了关于卫生棉条或杯子使用的建议。值得注意的是，我们的结果并没有表明月经杯比卫生棉条更安全，并表明它们需要类似的预防措施。
