再生医学策略在生物医学植入物中的应用。
Regenerative Medicine Strategies in Biomedical Implants.
机构信息
Regenerative Medicine and Disability Research (RMDR) Lab, Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Avenue, Rockford, IL,, 61007, USA.
出版信息
Curr Osteoporos Rep. 2018 Jun;16(3):236-245. doi: 10.1007/s11914-018-0441-0.
Abstract
PURPOSE OF REVIEW
Recently, significant progress has been made in the research related to regenerative medicine. At the same time, biomedical implants in orthopedics and dentistry are facing many challenges and posing clinical concerns. The purpose of this chapter is to provide an overview of the clinical applications of current regenerative strategies to the fields of dentistry and orthopedic surgery. The main research question in this review is: What are the major advancement strategies in regenerative medicine that can be used for implant research?
RECENT FINDINGS
The implant surfaces can be modified through patient-specific stem cells and plasma coatings, which may provide methods to improve osseointegration and sustainability of the implant. Overall understanding from the review suggesting that the outcome from the studies could lead to identify optimum solutions for many concerns in biomedical implants and even in drug developments as a long-term solution to orthopedic and dental patients.
摘要
目的综述：最近，再生医学的相关研究取得了重大进展。与此同时，骨科和牙科的生物医学植入物也面临着诸多挑战和临床问题。本章旨在概述当前再生策略在牙科和骨科领域的临床应用。本篇综述的主要研究问题是：有哪些主要的再生医学进展策略可用于植入物研究？
发现：可以通过患者特异性干细胞和等离子体涂层来修饰植入物表面，这可能为改善植入物的骨整合和可持续性提供方法。综述表明，这些研究的结果可能为生物医学植入物的许多问题找到最佳解决方案，甚至为长期解决骨科和牙科患者的问题提供药物开发的最佳解决方案。
相似文献
1
Regenerative Medicine Strategies in Biomedical Implants.再生医学策略在生物医学植入物中的应用。
Curr Osteoporos Rep. 2018 Jun;16(3):236-245. doi: 10.1007/s11914-018-0441-0.
2
Enhancing orthopedic implant bioactivity: refining the nanotopography.增强骨科植入物的生物活性：细化纳米形貌。
Nanomedicine (Lond). 2015;10(8):1327-41. doi: 10.2217/nnm.14.216.
3
Implants in bone: part I. A current overview about tissue response, surface modifications and future perspectives.骨植入物：第一部分。关于组织反应、表面改性及未来展望的当前概述。
Oral Maxillofac Surg. 2014 Sep;18(3):243-57. doi: 10.1007/s10006-013-0398-1. Epub 2013 Feb 24.
4
Biological strategies for improved osseointegration and osteoinduction of porous metal orthopedic implants.改善多孔金属骨科植入物骨整合和骨诱导的生物学策略。
Tissue Eng Part B Rev. 2015 Apr;21(2):218-30. doi: 10.1089/ten.TEB.2014.0333. Epub 2014 Dec 18.
5
Conus hip prosthesis.圆锥髋关节假体。
Acta Chir Orthop Traumatol Cech. 2001;68(4):213-21.
6
Osseointegrated Prosthetic Implants for People With Lower-Limb Amputation: A Health Technology Assessment.下肢截肢患者的骨整合假体植入物：一项卫生技术评估。
Ont Health Technol Assess Ser. 2019 Dec 12;19(7):1-126. eCollection 2019.
7
Current methods of preventing aseptic loosening and improving osseointegration of titanium implants in cementless total hip arthroplasty: a review.非骨水泥型全髋关节置换术中预防钛植入物无菌性松动及改善骨整合的当前方法：综述
J Int Med Res. 2018 Jun;46(6):2104-2119. doi: 10.1177/0300060517732697. Epub 2017 Nov 3.
8
Application of 3D-printed patient-specific skeletal implants augmented with autologous skeletal stem cells.应用自体骨骼干细胞增强的3D打印个性化骨骼植入物。
Regen Med. 2018 Apr;13(3):283-294. doi: 10.2217/rme-2017-0127. Epub 2018 May 1.
9
Osseointegration of titanium, titanium alloy and zirconia dental implants: current knowledge and open questions.钛、钛合金和氧化锆牙科种植体的骨整合：当前的知识和未解决的问题。
Periodontol 2000. 2017 Feb;73(1):22-40. doi: 10.1111/prd.12179.
10
Long-term survivorship of hip and knee arthroplasty.髋膝关节置换术的长期生存率
Bone Joint J. 2020 Apr;102-B(4):401-402. doi: 10.1302/0301-620X.102B4.BJJ-2020-0183.
引用本文的文献
1
Interface Performance Enhancement in 3D-Printed Biphasic Scaffolds with Interlocking Hourglass Geometry.具有互锁沙漏几何形状的3D打印双相支架的界面性能增强
Ann Biomed Eng. 2025 Jul 11. doi: 10.1007/s10439-025-03791-2.
2
Friction in soft biological systems and surface self-organization: the role of viscoelasticity.软生物系统中的摩擦与表面自组织：粘弹性的作用。
Biophys Rev. 2024 Oct 28;16(6):813-829. doi: 10.1007/s12551-024-01248-9. eCollection 2024 Dec.
3
Wirelessly Actuated Microfluidic Pump and Valve for Controlled Liquid Delivery in Dental Implants.用于牙种植体中可控液体输送的无线驱动微流泵和阀门
Adv Healthc Mater. 2024 Dec;13(31):e2402373. doi: 10.1002/adhm.202402373. Epub 2024 Aug 7.
4
Dental Implants with External Hex Inclined Shoulder in Full-Arch Immediate Loading Rehabilitations of the Maxilla.在上颌全牙弓即刻负重修复中使用带外部六角斜面肩台的牙种植体。
Dent J (Basel). 2024 May 8;12(5):131. doi: 10.3390/dj12050131.
5
Buccal Mesenchymal Stromal Cells as a Source of Osseointegration of Titanium Implants.颊侧间充质基质细胞作为钛植入物骨整合的来源。
Bull Exp Biol Med. 2024 Mar;176(5):620-625. doi: 10.1007/s10517-024-06080-5. Epub 2024 May 11.
6
Therapeutic potential of mesenchymal stem cell-derived exosomes for regenerative medicine applications.间充质干细胞衍生的外泌体在再生医学应用中的治疗潜力。
Clin Exp Med. 2024 Mar 1;24(1):46. doi: 10.1007/s10238-023-01282-z.
7
The current regenerative medicine approaches of craniofacial diseases: A narrative review.颅面疾病的当前再生医学方法：一项叙述性综述。
Front Cell Dev Biol. 2023 Feb 28;11:1112378. doi: 10.3389/fcell.2023.1112378. eCollection 2023.
8
Computed Tomography Imaging under Artificial Intelligence Reconstruction Algorithm Used in Recovery of Sports Injury of the Knee Anterior Cruciate Ligament.人工智能重建算法下的计算机断层成像在膝关节前交叉韧带运动损伤康复中的应用。
Contrast Media Mol Imaging. 2022 May 28;2022:1199841. doi: 10.1155/2022/1199841. eCollection 2022.
9
Dental and Orthopaedic Implant Loosening: Overlap in Gene Expression Regulation.牙科和骨科植入物松动：基因表达调控的重叠。
Front Immunol. 2022 Feb 11;13:820843. doi: 10.3389/fimmu.2022.820843. eCollection 2022.
10
Improve Integration of In Vitro Biofilm Body of Knowledge to Support Clinical Breakthroughs in Surgical Site Infection.提高体外生物膜知识库的整合水平，以支持手术部位感染的临床突破。
J Am Acad Orthop Surg Glob Res Rev. 2021 Nov 4;5(11):e20.00217. doi: 10.5435/JAAOSGlobal-D-20-00217.
本文引用的文献
1
Cellular Allograft in the Treatment of a Severe Periodontal Intrabony Defect: A Case Report.细胞同种异体移植治疗重度牙周骨内缺损：病例报告
Clin Adv Periodontics. 2012 Feb;2(1):35-39. doi: 10.1902/cap.2011.110017.
2
Lumbar Interbody Fusion: A Historical Overview and a Future Perspective.腰椎体间融合术：历史回顾与未来展望。
Spine (Phila Pa 1976). 2018 Aug;43(16):1161-1168. doi: 10.1097/BRS.0000000000002534.
3
How frequent does peri-implantitis occur? A systematic review and meta-analysis.种植体周围炎的发生频率有多高？一项系统评价和荟萃分析。
Clin Oral Investig. 2018 May;22(4):1805-1816. doi: 10.1007/s00784-017-2276-y. Epub 2017 Dec 7.
4
The role of cage height on the flexibility and load sharing of lumbar spine after lumbar interbody fusion with unilateral and bilateral instrumentation: a biomechanical study.椎间融合器高度对单侧及双侧内固定腰椎椎间融合术后腰椎灵活性及负荷分担的影响：一项生物力学研究
BMC Musculoskelet Disord. 2017 Nov 21;18(1):474. doi: 10.1186/s12891-017-1845-1.
5
Trends Analysis of rhBMP Utilization in Single-Level Posterior Lumbar Interbody Fusion in the United States.美国单节段腰椎后路椎间融合术中重组人骨形态发生蛋白（rhBMP）应用的趋势分析
Global Spine J. 2017 Oct;7(7):624-628. doi: 10.1177/2192568217699387. Epub 2017 Jun 30.
6
Combination of bone marrow mesenchymal stem cells sheet and platelet rich plasma for posterolateral lumbar fusion.骨髓间充质干细胞片与富血小板血浆联合用于腰椎后外侧融合术
Oncotarget. 2017 Jul 31;8(37):62298-62311. doi: 10.18632/oncotarget.19749. eCollection 2017 Sep 22.
7
Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells.具有复杂表面的钛生物材料会诱导骨髓间充质基质细胞外周昼夜节律异常。
PLoS One. 2017 Aug 17;12(8):e0183359. doi: 10.1371/journal.pone.0183359. eCollection 2017.
8
Bio-implant as a novel restoration for tooth loss.生物植入物作为一种新型的牙齿缺失修复方式。
Sci Rep. 2017 Aug 7;7(1):7414. doi: 10.1038/s41598-017-07819-z.
9
Injectable and compression-resistant low-viscosity polymer/ceramic composite carriers for rhBMP-2 in a rabbit model of posterolateral fusion: a pilot study.用于兔后外侧融合模型中重组人骨形态发生蛋白-2的可注射且抗压低粘度聚合物/陶瓷复合载体：一项初步研究。
J Orthop Surg Res. 2017 Jul 11;12(1):107. doi: 10.1186/s13018-017-0613-0.
10
Synergistic interactions between corrosion and wear at titanium-based dental implant connections: A scoping review.钛基牙种植体连接部位的腐蚀与磨损的协同作用：范围综述。
J Periodontal Res. 2017 Dec;52(6):946-954. doi: 10.1111/jre.12469. Epub 2017 Jun 14.
Zotero 插件