口腔扁平苔藓与汞合金相关口腔苔藓样病变中金属硫蛋白的差异表达
Differential metallothionein expression in oral lichen planus and amalgam-associated oral lichenoid lesions.
作者信息
Mendes G-G, Servato J-P-S, Borges F-C, Rosa R-R, Siqueira C-S, de Faria P-R, Loyola A-M, Cardoso S-V
机构信息
Universidade Federal de Uberlândia, Faculdade de Odontologia, Área de Patologia. Av. Pará, 1720, Campus Umuarama. CEP: 38405-320, Uberlândia - MG Brazil,
出版信息
Med Oral Patol Oral Cir Bucal. 2018 May 1;23(3):e262-e268. doi: 10.4317/medoral.22144.
BACKGROUND
Oral lichen planus (OLP) is a chronic inflammatory disease mediated by T cells, which manifests as reticular (white) or erosive (red) lesions, that are eventually painful. Oral lichenoid lesion (OLL) are distinguished from OLP by the presence of precipitating factors. The aim of this study was to evaluate whether the presence of metallothionein, which is involved in anti-apoptotic pathways and the anti-oxidative response, could serve as a differential diagnostic for OLP and OLL.
MATERIAL AND METHODS
We evaluated the expression of metallothionein in 40 cases of OLP and 20 cases of OLL using immunohistochemistry.
RESULTS AND CONCLUSIONS
White OLP has higher concentrations of metallothionein than red OLP in basal and parabasal layers. Moreover, metallothionein was more frequently observed in the cytoplasm and nuclei of basal cells in OLP patients compared to the same regions of OLL cases. Metallothionein levels are related to OLP severity and may contribute to a differential diagnosis between OLP and OLL.
背景
口腔扁平苔藓（OLP）是一种由T细胞介导的慢性炎症性疾病，表现为网状（白色）或糜烂性（红色）病变，最终会产生疼痛。口腔苔藓样病变（OLL）可通过诱发因素与OLP相鉴别。本研究的目的是评估参与抗凋亡途径和抗氧化反应的金属硫蛋白的存在是否可作为OLP和OLL的鉴别诊断指标。
材料与方法
我们采用免疫组织化学方法评估了40例OLP和20例OLL中金属硫蛋白的表达情况。
结果与结论
白色OLP在基底层和副基底层中的金属硫蛋白浓度高于红色OLP。此外，与OLL病例的相同区域相比，OLP患者基底层细胞的细胞质和细胞核中更频繁地观察到金属硫蛋白。金属硫蛋白水平与OLP的严重程度相关，可能有助于OLP和OLL的鉴别诊断。
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