Institute for Biomedical Engineering and College of Information Engineering, China Jiliang University, Hangzhou, China.
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Neural Plast. 2018 Feb 28;2018:4756471. doi: 10.1155/2018/4756471. eCollection 2018.
During the past several years, the rapid development of neuroimaging techniques has contributed greatly in the noninvasive imaging studies of tinnitus. The aim of the present study was to explore the brain anatomical alterations in patients with right-sided unilateral pulsatile tinnitus (PT) in the early stage of PT symptom using voxel-based morphometry (VBM) analysis. Twenty-four patients with right-sided pulsatile tinnitus and 24 age- and gender-matched normal controls were recruited to this study. Structural image data preprocessing was performed using VBM8 toolbox. Tinnitus Handicap Inventory (THI) score was acquired in the tinnitus group to assess the severity of tinnitus and tinnitus-related distress. Two-sample -test and Pearson's correlation analysis were used in statistical analysis. Patients with unilateral pulsatile tinnitus had significantly increased gray matter (GM) volume in bilateral superior temporal gyrus compared with the normal controls. However, the left cerebellum posterior lobe, left frontal superior orbital lobe (gyrus rectus), right middle occipital gyrus (MOG), and bilateral putamen showed significantly decreased brain volumes. This was the first study which demonstrated the features of neuroanatomical changes in patients with unilateral PT during their early stages of the symptom.
在过去的几年中，神经影像学技术的快速发展极大地促进了非侵入性耳鸣影像学研究。本研究旨在使用基于体素的形态测量学（VBM）分析探讨早期右侧搏动性耳鸣（PT）患者的脑解剖结构改变。本研究纳入了 24 例右侧搏动性耳鸣患者和 24 名年龄和性别匹配的正常对照者。使用 VBM8 工具箱对结构图像数据进行预处理。在耳鸣组中获取耳鸣残疾量表（THI）评分，以评估耳鸣的严重程度和与耳鸣相关的困扰。在统计分析中使用了双样本 t 检验和 Pearson 相关分析。与正常对照组相比，单侧搏动性耳鸣患者双侧颞上回的灰质（GM）体积明显增加。然而，左侧小脑后叶、左侧额上直回、右侧中枕回（MOG）和双侧壳核的脑体积明显减少。这是第一项研究，表明单侧 PT 患者在症状早期的神经解剖结构变化特征。
