Wei Xuan, Lv Han, Wang Zhaodi, Liu Chunli, Ren Pengling, Zhang Peng, Chen Qian, Liu Yawen, Zhao Pengfei, Gong Shusheng, Yang Zhenghan, Wang Zhenchang
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Front Neurosci. 2020 Sep 8;14:911. doi: 10.3389/fnins.2020.00911. eCollection 2020.
According to previous studies, many neuroanatomical alterations have been detected in patients with tinnitus. However, few studies have reported on the morphological changes observed following sound therapy. To explore the brain anatomical alterations in patients with idiopathic tinnitus using voxel-based morphometry (VBM) analysis before and after effective 12 weeks sound therapy. The protocol was registered on ClinicalTrials.gov, ID: NCT02774122. In this study, we collected data from 27 matched healthy control (HC) individuals and 27 idiopathic tinnitus patients before and after 12 weeks of sound therapy by using adjusted narrow band sound. 3.0T MRI system and high-resolution 3D structural images were acquired with a 3D-BRAVO pulse sequence. Structural image data preprocessing was performed using the VBM8 toolbox. The Tinnitus Handicap Inventory (THI) score was acquired in the tinnitus group to assess the severity of tinnitus and tinnitus-related distress. Mann-Whitney Test, Wilcoxon Signed-Ranks test, and Pearson's correlation analysis were used in the statistical analysis. We found significantly decreased gray matter (GM) volume in the left thalami, right thalami, and cochlear nucleus among the tinnitus patients before sound therapy (baseline) compared to the HC group. However, we did not find significant differences in brain regions between the 12-week treatment and HC groups. According to the results of Wilcoxon Signed-Ranks test, the 12-week sound therapy group demonstrated significant greater brain volume compared with the baseline group among these brain regions. Decreased THI score and changed GM volume were not correlated. This is a useful study for observing the characteristics of neuroanatomical changes in patients with idiopathic tinnitus before and after sound treatment. The study characterized the effect of sound therapy on brain volume. It found that sound therapy had a normalizing effect on the bilateral thalami and cochlear nucleus. www.ClinicalTrials.gov, NCT02774122.
根据先前的研究，耳鸣患者已检测出许多神经解剖学改变。然而，很少有研究报道声音疗法后观察到的形态学变化。为了使用基于体素的形态学测量（VBM）分析，探索特发性耳鸣患者在12周有效声音疗法前后的脑解剖学改变。该方案已在ClinicalTrials.gov上注册，编号：NCT02774122。在本研究中，我们收集了27名匹配的健康对照（HC）个体以及27名特发性耳鸣患者在12周声音疗法前后的数据，声音疗法采用调整后的窄带声音。使用3D-BRAVO脉冲序列，通过3.0T MRI系统采集高分辨率3D结构图像。使用VBM8工具箱进行结构图像数据预处理。在耳鸣组中获取耳鸣障碍量表（THI）评分，以评估耳鸣的严重程度和与耳鸣相关的痛苦。统计分析采用曼-惠特尼检验、威尔科克森符号秩检验和皮尔逊相关分析。我们发现，与HC组相比，耳鸣患者在声音疗法前（基线）左侧丘脑、右侧丘脑和耳蜗核中的灰质（GM）体积显著减少。然而，我们未发现12周治疗组与HC组之间在脑区上存在显著差异。根据威尔科克森符号秩检验的结果，在这些脑区中，12周声音疗法组与基线组相比，脑体积显著增大。THI评分降低与GM体积变化不相关。这是一项观察特发性耳鸣患者在声音治疗前后神经解剖学变化特征的有用研究。该研究描述了声音疗法对脑体积的影响。研究发现声音疗法对双侧丘脑和耳蜗核具有归一化作用。www.ClinicalTrials.gov，NCT02774122。
