Lv Han, Zhao Pengfei, Liu Zhaohui, Wang Guopeng, Zeng Rong, Yan Fei, Dong Cheng, Zhang Ling, Li Rui, Wang Peng, Li Ting, Gong Shusheng, Wang Zhenchang
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China; Neuroradiology Division, Department of Radiology, Stanford University, Stanford, CA 94305, USA.
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Neural Plast. 2016;2016:4918186. doi: 10.1155/2016/4918186. Epub 2016 Jun 20.
Previous resting-state functional magnetic resonance imaging (rs-fMRI) studies have shown that neurological changes are important findings in vascular pulsatile tinnitus (PT) patients. Here, we utilized rs-fMRI to measure the amplitude of low-frequency fluctuations (ALFF) in forty patients with unilateral PT and forty age-, gender-, and education-matched normal control subjects. Two different frequency bands (slow-4, 0.027-0.073 Hz, and slow-5, 0.010-0.027 Hz, which are more sensitive to subcortical and cortical neurological signal changes, resp.) were analyzed to examine the intrinsic brain activity in detail. Compared to controls, PT patients had increased ALFF values mainly in the PCu, bilateral IPL (inferior parietal lobule), left IFG (inferior frontal gyrus), and right IFG/anterior insula and decreased ALFF values in the multiple occipital areas including bilateral middle-inferior occipital lobe. For the differences of the two frequency bands, widespread ALFF differences were observed. The ALFF abnormalities in aMPFC/ACC, PCu, right IPL, and some regions of occipital and parietal cortices were greater in the slow-5 band compared to the slow-4 band. Additionally, the THI score of PT patients was positively correlated with changes in slow-5 and slow-4 band in PCu. Pulsatile tinnitus is a disease affecting the neurological activities of multiple brain regions. Slow-5 band is more sensitive in detecting the alternations. Our results also indicated the importance of pathophysiological investigations in patients with pulsatile tinnitus in the future.
以往的静息态功能磁共振成像（rs-fMRI）研究表明，神经学变化是血管搏动性耳鸣（PT）患者的重要发现。在此，我们利用rs-fMRI测量了40例单侧PT患者以及40例年龄、性别和教育程度相匹配的正常对照者的低频波动幅度（ALFF）。分析了两个不同的频段（慢4频段，0.027 - 0.073Hz，以及慢5频段，0.010 - 0.027Hz，分别对皮层下和皮层神经信号变化更敏感）以详细检查大脑的内在活动。与对照组相比，PT患者主要在楔前叶、双侧顶下小叶（IPL）、左侧额下回（IFG）以及右侧IFG/前岛叶的ALFF值增加，而在包括双侧枕叶中下部在内的多个枕叶区域ALFF值降低。对于两个频段的差异，观察到广泛的ALFF差异。与慢4频段相比，在慢5频段中，前扣带回/前扣带皮层（aMPFC/ACC）、楔前叶、右侧顶下小叶以及枕叶和顶叶皮层的一些区域的ALFF异常更为明显。此外，PT患者的耳鸣障碍指数（THI）评分与楔前叶慢5和慢4频段的变化呈正相关。搏动性耳鸣是一种影响多个脑区神经活动的疾病。慢5频段在检测这些改变方面更敏感。我们的结果还表明了未来对搏动性耳鸣患者进行病理生理学研究的重要性。
