选择行保留生育功能手术治疗的卵巢癌患者的生存情况。

Survival of selected patients with ovarian cancer treated with fertility-sparing surgery.

机构信息

Department of Gynaecology and Obstetrics, Rigshospitalet, Denmark.

出版信息

Reprod Biomed Online. 2018 Jul;37(1):71-76. doi: 10.1016/j.rbmo.2018.03.018. Epub 2018 Apr 11.

DOI:10.1016/j.rbmo.2018.03.018

PMID:29685481

Abstract

RESEARCH QUESTION

How many patients in Denmark were treated with fertility-sparing surgery (FSS) for epithelial ovarian cancer (EOC) and what was their prognosis compared with patients treated with radical surgery (RS)?

DESIGN

This study was a retrospective Danish nationwide study, evaluating the effect of FSS compared with RS in patients with EOC, age ≤45 years and International Federation of Gynecology and Obstetrics (FIGO) stage ≤IC3 from 2005 to 2016.

RESULTS

A total of 106 patients were included. Of these, 13 were treated with FSS and 93 were treated with RS. Median age was 27 versus 42 years (P < 0.0001). Overall survival did not differ significantly between the two groups. Overall survival rate in the FSS group was 100%, while the overall survival in the RS group was 87%. Disease-specific survival was 100% in the FSS group and 91% in the RS group.

CONCLUSIONS

This study shows that patients treated with FSS for FIGO stage I EOC do not have an impaired survival compared with patients treated with RS. Nevertheless, the conclusion must be interpreted with caution due to the limited number of patients and the retrospective nature of the study. Larger studies are needed before conclusions can be drawn.

摘要

研究问题

在丹麦，有多少上皮性卵巢癌（EOC）患者接受了保留生育功能的手术（FSS）治疗，与接受根治性手术（RS）治疗的患者相比，他们的预后如何？

设计

本研究是一项回顾性丹麦全国性研究，评估了 2005 年至 2016 年期间，年龄≤45 岁且国际妇产科联合会（FIGO）分期≤IC3 的 EOC 患者接受 FSS 与 RS 治疗的效果。

结果

共纳入 106 例患者，其中 13 例接受 FSS 治疗，93 例接受 RS 治疗。中位年龄分别为 27 岁和 42 岁（P<0.0001）。两组患者的总生存率无显著差异。FSS 组的总生存率为 100%，而 RS 组的总生存率为 87%。FSS 组的疾病特异性生存率为 100%，RS 组为 91%。