人类免疫缺陷病毒疾病长期并发症的管理：聚焦心血管疾病
Management of Long-Term Complications of HIV Disease: Focus on Cardiovascular Disease.
作者信息
Currier Judith S
机构信息
University of California Los Angeles, Los Angeles, CA, USA.
出版信息
Top Antivir Med. 2018 Apr;25(4):133-137.
Abstract
HIV-infected individuals on effective antiretroviral therapy experience a number of non-AIDS noncommunicable diseases, such as cardiovascular disease, more frequently than uninfected individuals. Common pathways for such diseases are chronic immune activation and inflammation, including the prolonged inflammation associated with lower nadir CD4+ cell count. Prevention and treatment of non-AIDS conditions include treatment of traditional risk factors, lifestyle interventions, earlier initiation of antiretroviral therapy, and potentially therapies specifically targeting inflammation and immune activation (eg, statins). This article summarizes a presentation by Judith S. Currier, MD, at the IAS-USA continuing education program, Improving the Management of HIV Disease, held in New York, New York, in February 2017.
摘要
接受有效抗逆转录病毒治疗的HIV感染者比未感染者更频繁地经历一些非艾滋病非传染性疾病，如心血管疾病。这些疾病的常见途径是慢性免疫激活和炎症，包括与较低的最低点CD4 +细胞计数相关的长期炎症。非艾滋病疾病的预防和治疗包括治疗传统危险因素、生活方式干预、更早开始抗逆转录病毒治疗，以及可能专门针对炎症和免疫激活的疗法（如他汀类药物）。本文总结了医学博士朱迪思·S·柯里尔在2017年2月于纽约市举行的IAS-USA继续教育项目“改善HIV疾病管理”上的一次演讲。
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