一项回顾性队列研究，研究了合并和不合并结核分枝杆菌（TB）感染的 HIV 感染者的体重指数（BMI）与生存情况。
A retrospective cohort study of body mass index and survival in HIV infected patients with and without TB co-infection.
机构信息
Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, 2nd Floor Doris Duke Medical Research Institute, Private Bag X7, Durban, Congella, 4013, South Africa.
MRC-CAPRISA HIV-TB Pathogenesis and Treatment Research Unit, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
出版信息
Infect Dis Poverty. 2018 Apr 25;7(1):35. doi: 10.1186/s40249-018-0418-3.
BACKGROUND
High early morbidity and mortality following antiretroviral therapy (ART) initiation has been a distinguishing feature of ART programmes in resource limited settings (RLS) compared to high-income countries. This study assessed how well body mass index (BMI: kg/m) correlated with survival among HIV infected patients with and without TB co-infection.
METHODS
We retrospectively evaluated clinical data from 1000 HIV infected patients, among whom 389 were also co-infected with TB, between January 2008 and December 2010, in KwaZulu-Natal, South Africa.
RESULTS
Among 948 patients eligible for analysis, 15.7% (149/948) were underweight (< 18.50), 55.9% (530/948) had normal BMI (≥18.50-24.90), 18.7% (177/948) were overweight (25.00-29.00) and 9.7% (92/948) were obese (≥30.00). Irrespective of TB status, underweight patients, had significantly higher risk of death compared to those with normal BMI at baseline (aHR = 2.9; 95% CI: 1.5-5.7; P = 0.002).
CONCLUSIONS
Irrespective of TB co-infection, low BMI correlated with mortality in HIV infected patients.
TRIAL REGISTRATION
UKZN Biomedical Research Ethics Committee Reference number E 248/05, 23 September 2005.
背景
与高收入国家相比，在资源有限的环境（RLS）中，抗逆转录病毒疗法（ART）启动后早期高发病率和死亡率一直是 ART 项目的一个显著特征。本研究评估了体重指数（BMI：kg/m）与 HIV 感染患者合并和不合并结核病（TB）感染的生存情况的相关性。
方法
我们回顾性评估了 2008 年 1 月至 2010 年 12 月期间在南非夸祖鲁-纳塔尔省的 1000 名 HIV 感染患者（其中 389 名同时合并 TB 感染）的临床数据。
结果
在 948 名符合分析条件的患者中，15.7%（149/948）体重不足（<18.50），55.9%（530/948）体重正常（≥18.50-24.90），18.7%（177/948）超重（25.00-29.00），9.7%（92/948）肥胖（≥30.00）。无论 TB 状态如何，与基线时体重正常的患者相比，体重不足的患者死亡风险显著更高（调整后的 HR=2.9；95%CI：1.5-5.7；P=0.002）。
结论
无论是否合并结核病，低 BMI 与 HIV 感染患者的死亡率相关。
试验注册
UKZN 生物医学伦理委员会注册号 E 248/05，2005 年 9 月 23 日。
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