Harvard Medical School and Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA, USA.
Trends Endocrinol Metab. 2018 Oct;29(10):667-668. doi: 10.1016/j.tem.2018.04.004. Epub 2018 Apr 21.
The miR-33 microRNAs (miRNAs) are crucial regulators of cholesterol/lipids, and may represent therapeutic targets for the treatment of atherosclerosis. A recent report by Price et al. showed that miR-33 knockout (KO) mice exhibit obesity, insulin resistance, and increased food intake, suggesting that metabolic regulation by miR-33 is more complex than was previously known.
miR-33 微 RNA（miRNAs）是胆固醇/脂质的关键调节因子，可能代表了动脉粥样硬化治疗的治疗靶点。Price 等人的最近报告表明，miR-33 敲除（KO）小鼠表现出肥胖、胰岛素抵抗和食物摄入增加，这表明 miR-33 的代谢调节比以前所知的更为复杂。
