Golden Eleza T, Dickson Paula, Simoneaux Stephen
Department of Radiology and Imaging Sciences, Children's Healthcare of Atlanta and Emory University, 1405 Clifton Road NE, Atlanta, Georgia 30322.
Indian J Radiol Imaging. 2018 Jan-Mar;28(1):107-110. doi: 10.4103/ijri.IJRI_67_17.
To describe the radiographic appearance of subclinical calcified brown fat necrosis and the associated clinical and laboratory findings.
Picture Archiving and Communications Sytem (PACS) was searched using keywords "soft tissue calcification" and "chest." The clinical record was searched for prior cardiac surgery, bypass, Extracorporeal Membrane Oxygentation (ECMO) and prostaglandin use. Age when calcifications were first detected, location, resolution, and associated laboratory abnormalities were recorded.
Nine patients were identified. None had skin lesions. All patients had congenital heart disease and had experienced cardiac/respiratory arrest and/or severe hypotension 1-6 weeks before soft tissue calcifications occurred. Calcifications resolved by 9 weeks to 5 months in 3 patients. The remaining were either deceased or lacked follow-up imaging. Renal ultrasound was performed in all but 1 patient. Nephrocalcinosis was only seen in 1 patient.
Brown fat necrosis is subclinical, diagnosed on plain film, and likely self-limited. It occurs in term and preterm infants who have undergone significant systemic stress and carries a poor prognosis.
描述亚临床钙化性棕色脂肪坏死的影像学表现以及相关的临床和实验室检查结果。
使用关键词“软组织钙化”和“胸部”在图像存档与通信系统（PACS）中进行检索。在临床记录中查找既往心脏手术、旁路手术、体外膜肺氧合（ECMO）和前列腺素使用情况。记录首次发现钙化时的年龄、位置、消退情况以及相关的实验室异常。
共识别出9例患者。均无皮肤病变。所有患者均患有先天性心脏病，且在软组织钙化出现前1 - 6周经历过心脏/呼吸骤停和/或严重低血压。3例患者的钙化在9周内至5个月内消退。其余患者要么死亡，要么缺乏后续影像学检查。除1例患者外，所有患者均进行了肾脏超声检查。仅1例患者出现肾钙质沉着症。
棕色脂肪坏死是亚临床性的，通过平片诊断，可能为自限性。它发生在经历过重大全身应激的足月儿和早产儿中，预后较差。
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