Allavena P, Lo Presti P, Di Bello M, Lucchini V, Lissoni A, Zanetta G, Mangioni C, Mantovani A
Laboratory of Human Immunology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Cancer Immunol Immunother. 1988;27(1):69-76. doi: 10.1007/BF00205761.
Peripheral blood lymphocytes (PBL) from 43 patients with histologically confirmed ovarian carcinoma were stimulated in mixed lymphocyte-tumor culture (MLTC) with purified autologous tumor cells. Positive results, assessed as lymphocyte proliferation, were observed in 21 cases (48.8%). Lymphoid cells associated with ascitic fluid or infiltrating solid masses were in general less reactive than PBL as only 3/11 cases had positive MLTC. Tumor cells isolated from peritoneal effusions showed no significant difference in stimulatory potential as compared to the primary tumor. These results suggest that in an appreciable proportion of ovarian carcinoma patients (approximately 50%), lymphocytes have the potential to react to autologous tumor cells. Comprehension of the immunological mechanisms of antitumor resistance may have direct practical relevance for more effective treatment of neoplasms.
对43例经组织学确诊的卵巢癌患者的外周血淋巴细胞（PBL），采用纯化的自体肿瘤细胞在混合淋巴细胞-肿瘤培养（MLTC）中进行刺激。以淋巴细胞增殖评估的阳性结果在21例（48.8%）中观察到。与腹水或浸润性实体肿块相关的淋巴细胞通常比PBL反应性低，因为只有3/11的病例MLTC呈阳性。从腹腔积液中分离出的肿瘤细胞与原发性肿瘤相比，刺激潜能无显著差异。这些结果表明，在相当比例（约50%）的卵巢癌患者中，淋巴细胞有对自体肿瘤细胞产生反应的潜力。理解抗肿瘤抗性的免疫机制可能对肿瘤的更有效治疗具有直接的实际意义。
