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甲钴胺和抗坏血酸对绝经后女性认知功能的比较评估——一项随机双盲试验

Comparative assessment of methylcobalamin and ascorbic acid on cognitive function in post-menopausal women - A randomized, double-blind trial.

作者信息

Vijayakumar Thangavel Mahalingam, Pavitra Kumaraswamy, Muthunarayanan Logaraj

机构信息

Department of Pharmacy Practice, SRM College of Pharmacy, SRM University, Kattankulathur, 603 203, Tamil Nadu, India.

Department of Community Medicine, SRM Medical College Hospital and Research Centre, Kattankulathur, 603 203, Tamil Nadu, India.

出版信息

Contemp Clin Trials Commun. 2017 Oct 16;8:175-180. doi: 10.1016/j.conctc.2017.10.006. eCollection 2017 Dec.

DOI:10.1016/j.conctc.2017.10.006
PMID:29696207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5898509/
Abstract

INTRODUCTION

A decline in cognitive function occurs as women progress through the menopausal transition.

OBJECTIVE

The present study was designed to compare the effect of Methylcobalamin and Ascorbic Acid on Cognitive Function in post-menopausal women.

METHODS

A randomized, double-blind trial was conducted in postmenopausal women with mild to moderate cognitive dysfunction. Eligible 56 subjects were randomized, the effect of ascorbic acid (500 mg OD) and methylcobalamin (50 mcg OD) was compared after 12 weeks of treatment. MMSE Questionnaire was used to assess the cognitive function, and β-amyloid42 was estimated in serum by enzyme-linked immunosorbent assay (ELISA).

RESULTS

In MMSE score, delayed verbal recall ( = 0.027), naming ( = 0.042) and repetition ( = 0.031) scores were significantly improved in ascorbic acid group when compared to baseline. The β-amyloid42 level was decreased significantly in subjects receiving ascorbic acid ( = 0.04) when compared to Methylcobalamin group ( = 0.31). The inverse relationship between β-amyloid42 levels and the MMSE score was found in ascorbic acid treatment ( = 0.6324,  = 0.0004).

CONCLUSION

Based on MMSE and β-amyloid42 results, ascorbic acid showed improvement in cognitive function among post-menopausal women when compared to methylcobalamin supplement.

摘要

引言

随着女性经历绝经过渡，认知功能会出现下降。

目的

本研究旨在比较甲钴胺和抗坏血酸对绝经后女性认知功能的影响。

方法

对患有轻度至中度认知功能障碍的绝经后女性进行了一项随机双盲试验。56名符合条件的受试者被随机分组，在治疗12周后比较抗坏血酸（500毫克每日一次）和甲钴胺（50微克每日一次）的效果。使用简易精神状态检查表（MMSE）问卷评估认知功能，并通过酶联免疫吸附测定（ELISA）法测定血清中的β淀粉样蛋白42。

结果

在MMSE评分中，与基线相比，抗坏血酸组的延迟言语回忆（P = 0.027）、命名（P = 0.042）和复述（P = 0.031）得分显著提高。与甲钴胺组（P = 0.31）相比，接受抗坏血酸治疗的受试者β淀粉样蛋白42水平显著降低（P = 0.04）。在抗坏血酸治疗中发现β淀粉样蛋白42水平与MMSE评分呈负相关（r = 0.6324，P = 0.0004）。

结论

基于MMSE和β淀粉样蛋白42的结果，与补充甲钴胺相比，抗坏血酸在绝经后女性认知功能方面显示出改善作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ea/5898509/ab4f7c61e84e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ea/5898509/0c7012f8ff63/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ea/5898509/a7eec9f460f7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ea/5898509/724563b87a07/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ea/5898509/ab4f7c61e84e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ea/5898509/0c7012f8ff63/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ea/5898509/a7eec9f460f7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ea/5898509/724563b87a07/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ea/5898509/ab4f7c61e84e/gr4.jpg

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