Elizabeth Glaser Pediatric AIDS Foundation, MVA Office Park, Corner of Mbhilibhi and Tsekwane Streets, P.O. Box A507, Mbabane, H100, Swaziland.
Elizabeth Glaser Pediatric AIDS Foundation, Washington, DC, USA.
AIDS Behav. 2018 Jul;22(Suppl 1):105-113. doi: 10.1007/s10461-018-2121-6.
In Swaziland, no data are available on the rates of HIV infection and HIV-free survival among children at the end of the breastfeeding period. We performed a national crosssectional community survey of children born 18-24 months prior to the study, in randomly selected constituencies in all 4 administrative regions of Swaziland, from April to June 2015. Mother-to-child transmission (MTCT) of HIV and HIV-free survival rates were calculated for all HIV-exposed children. The overall HIV-free survival rate at 18-24 months was 95.9% (95% CI 94.1-97.2). The estimated proportion of HIV infected children among known HIV-exposed children was 3.6% (95% CI 2.4-5.2). Older maternal age, delivering at a health facility, and receiving antenatal antiretroviral drugs were independently associated with reduced risk for child infection or death. The Swaziland program for prevention of MTCT achieved high HIV-free survival (95.9%) and low MTCT (3.6%) rates at 18-24 months of age when Option A (infant prophylaxis) of the WHO 2010 guidelines was implemented.
在斯威士兰，没有关于母乳喂养期末期儿童艾滋病毒感染率和艾滋病毒无生存者的数据。我们于 2015 年 4 月至 6 月期间在斯威士兰所有 4 个行政区的随机选区中，对在研究前 18-24 个月出生的儿童进行了全国性的横断面社区调查。对所有艾滋病毒暴露儿童计算了母婴传播（MTCT）的艾滋病毒和艾滋病毒无生存者的比率。18-24 个月时的艾滋病毒无生存者总体比率为 95.9%（95%CI 94.1-97.2）。已知艾滋病毒暴露儿童中艾滋病毒感染儿童的估计比例为 3.6%（95%CI 2.4-5.2）。母亲年龄较大、在医疗机构分娩和接受产前抗逆转录病毒药物治疗与儿童感染或死亡风险降低独立相关。当执行世卫组织 2010 年指南的选项 A（婴儿预防）时，斯威士兰的母婴传播预防方案在 18-24 个月龄时实现了高艾滋病毒无生存者（95.9%）和低母婴传播（3.6%）率。
