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不同注射部位及不同途径接种乙型肝炎疫苗的免疫反应：一项对照随机研究

Immune response to hepatitis B vaccine given at different injection sites and by different routes: a controlled randomized study.

作者信息

de Lalla F, Rinaldi E, Santoro D, Pravettoni G

机构信息

Department of Infectious Diseases, S. Anna Hospital, Milan, Italy.

出版信息

Eur J Epidemiol. 1988 Jun;4(2):256-8. doi: 10.1007/BF00144763.

DOI:10.1007/BF00144763
PMID:2969825
Abstract

Two-hundred-ninety-nine hospital workers were randomly allocated to receive MSD hepatitis B vaccine in different injection sites and by different routes (intramuscularly by gluteal or deltoid injections or subcutaneously in the arm) or Pasteur vaccine subcutaneously. Highest rates of seroconversion and highest mean anti-HB, titres were found in subjects given MSD vaccine by intramuscular injection into the deltoid muscle.

摘要

299名医院工作人员被随机分配，分别在不同注射部位、通过不同途径接种默克公司生产的乙肝疫苗（经臀肌或三角肌进行肌肉注射，或在手臂进行皮下注射），或皮下接种巴斯德疫苗。结果发现，通过三角肌肌肉注射接种默克公司疫苗的受试者血清转化率最高，抗-HB平均滴度也最高。

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Immune response to hepatitis B vaccine given at different injection sites and by different routes: a controlled randomized study.不同注射部位及不同途径接种乙型肝炎疫苗的免疫反应：一项对照随机研究
Eur J Epidemiol. 1988 Jun;4(2):256-8. doi: 10.1007/BF00144763.
2
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Med J Aust. 1987 Mar 2;146(5):242-5.
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Response to deltoid muscle injection of hepatitis B vaccine after failure to respond to gluteal injections.臀肌注射乙肝疫苗无反应后三角肌注射的反应
JAMA. 1986 Apr 25;255(16):2157.
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Effect of anatomic injection site, age and smoking on the immune response to hepatitis B vaccination.
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Suboptimal response to hepatitis B vaccine given by injection into the buttock.通过臀部注射给予乙肝疫苗的反应欠佳。
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Leads from the MMWR. Suboptimal response to hepatitis B vaccine given by injection into the buttock.《发病率与死亡率周报》导言。经臀部注射给予乙型肝炎疫苗后反应欠佳。
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Comparison of results for phase I studies with recombinant and plasma-derived hepatitis B vaccines, and controlled study comparing intramuscular and subcutaneous injections of recombinant hepatitis B vaccine.重组乙肝疫苗与血浆源性乙肝疫苗的I期研究结果比较，以及重组乙肝疫苗肌内注射与皮下注射的对照研究。
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本文引用的文献

1
Site of injection and response to hepatitis B vaccine.注射部位与乙肝疫苗反应
N Engl J Med. 1985 Aug 29;313(9):579-80. doi: 10.1056/NEJM198508293130911.
2
Suboptimal response to hepatitis B vaccine given by injection into the buttock.通过臀部注射给予乙肝疫苗的反应欠佳。
MMWR Morb Mortal Wkly Rep. 1985 Mar 1;34(8):105-8, 113.
3
Response to deltoid muscle injection of hepatitis B vaccine after failure to respond to gluteal injections.臀肌注射乙肝疫苗无反应后三角肌注射的反应
Subcutaneous vaccine administration - an outmoded practice.
皮下疫苗接种——一种过时的做法。
Hum Vaccin Immunother. 2021 May 4;17(5):1329-1341. doi: 10.1080/21645515.2020.1814094. Epub 2020 Sep 29.
4
The SENIEUR protocol and the efficacy of hepatitis B vaccination in healthy elderly persons by age, gender, and vaccine route.SENIEUR方案以及按年龄、性别和疫苗接种途径划分的健康老年人中乙型肝炎疫苗接种的效果。
Immun Ageing. 2020 Apr 28;17:9. doi: 10.1186/s12979-020-00179-9. eCollection 2020.
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Recent Progress on the Versatility of Virus-Like Particles.病毒样颗粒多功能性的最新进展
Vaccines (Basel). 2020 Mar 20;8(1):139. doi: 10.3390/vaccines8010139.
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2019 meeting of the global virus network.2019 年全球病毒网络会议。
Antiviral Res. 2019 Dec;172:104645. doi: 10.1016/j.antiviral.2019.104645. Epub 2019 Nov 4.
7
Safety and immunogenicity of a Herpes Zoster subunit vaccine in Japanese population aged ≥50 years when administered subcutaneously vs. intramuscularly.≥50岁日本人群中，带状疱疹亚单位疫苗皮下注射与肌肉注射的安全性及免疫原性。
Hum Vaccin Immunother. 2017 Mar 4;13(3):574-578. doi: 10.1080/21645515.2016.1232787. Epub 2016 Dec 9.
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Effect of vaccine administration modality on immunogenicity and efficacy.疫苗接种方式对免疫原性和疗效的影响。
Expert Rev Vaccines. 2015;14(11):1509-23. doi: 10.1586/14760584.2015.1081067. Epub 2015 Aug 27.
9
Hepatitis B vaccination during pregnancy for preventing infant infection.孕期接种乙肝疫苗以预防婴儿感染。
Cochrane Database Syst Rev. 2014 Nov 11;2014(11):CD007879. doi: 10.1002/14651858.CD007879.pub3.
10
Hepatitis B virus: where do we stand and what is the next step for eradication?乙型肝炎病毒：我们目前的状况如何，根除的下一步是什么？
World J Gastroenterol. 2014 Jul 21;20(27):8998-9016. doi: 10.3748/wjg.v20.i27.8998.
JAMA. 1986 Apr 25;255(16):2157.
4
Hepatitis B vaccine: low postvaccination immunity in hospital personnel given gluteal injections.乙肝疫苗：接受臀肌注射的医院工作人员接种疫苗后免疫力较低。
Hepatology. 1985 Nov-Dec;5(6):1088-90. doi: 10.1002/hep.1840050605.
5
Low immune responses to hepatitis B vaccination among healthy subjects.健康受试者对乙肝疫苗的低免疫反应。
Lancet. 1985 May 18;1(8438):1152. doi: 10.1016/s0140-6736(85)92449-3.