Nakagawa Koji, Nishi Yayoi, Sugiyama Rie, Jyuen Hiroyasu, Takahashi Chie, Ojiro Yuko, Kuribayashi Yasushi, Sugiyama Rikikazu
Division of Reproductive Medicine Sugiyama Clinic 1-53-1, Ohara, Setagaya 156-0041 Tokyo Japan.
Reprod Med Biol. 2011 Sep 20;11(2):85-89. doi: 10.1007/s12522-011-0110-9. eCollection 2012 Apr.
The purpose was to establish a mild ovarian stimulation protocol that would help assisted reproductive technology (ART) units to avoid scheduling on weekends.
This protocol directed patients to take 50 mg/day of clomiphene citrate between days 3 and 7 of the menstrual cycle: 225 IU of recombinant follicle-stimulating hormone (rec-FSH) were administered on days 3, 5 and 7; human chorionic gonadotropin (hCG) was administered on day 9; and, oocyte pick-up (OPU) was planned for day 11. From October 2008 through October 2009, 514 women underwent ART treatment with mild stimulation at the Sugiyama Clinic, and we evaluated whether OPU was accomplished on the planned day.
Of all the treatment cycles, 419 (81.5%) underwent OPU on day 11 (scheduled group). Additional rec-FSH administration was needed in 83 cycles, in which case OPU was performed on day 12 or later. In 12 cycles, OPU was canceled. The unscheduled group ( = 95) consisted of delayed OPU cycles and canceled cycles. Of all treatment cycles, 332 cycles in the scheduled group and 68 cycles in the unscheduled group underwent embryo transfer, with 81 and 16, respectively, resulting in pregnancies.
Using this protocol, OPU was performed on the scheduled day in about 80% of the cycles. Most weekend scheduling of OPU can be avoided using this mild stimulation.
旨在建立一种温和的卵巢刺激方案，以帮助辅助生殖技术（ART）单位避免在周末安排手术。
该方案指导患者在月经周期的第3至7天每天服用50毫克枸橼酸氯米芬：在第3、5和7天给予225国际单位的重组促卵泡激素（rec-FSH）；在第9天给予人绒毛膜促性腺激素（hCG）；并计划在第11天进行卵母细胞采集（OPU）。从2008年10月至2009年10月，514名女性在杉山诊所接受了温和刺激的ART治疗，我们评估了OPU是否在计划日完成。
在所有治疗周期中，419个（81.5%）在第11天进行了OPU（计划组）。83个周期需要额外给予rec-FSH，在这种情况下，OPU在第12天或更晚进行。在12个周期中，OPU被取消。非计划组（=95）包括OPU延迟的周期和取消的周期。在所有治疗周期中，计划组的332个周期和非计划组的68个周期进行了胚胎移植，分别有81个和16个周期成功妊娠。
使用该方案，约80%的周期在计划日进行了OPU。使用这种温和刺激可以避免大多数OPU的周末安排。
