Sugiyama Rikikazu, Nakagawa Koji, Nishi Yayoi, Ojiro Yuko, Juen Hiroyasu, Sugiyama Rie, Kuribayashi Yasushi
Division of Reproductive Medicine Sugiyama Clinic 1-53-1 Ohara, Setagaya-ku 156-0041 Tokyo Japan.
Center for Reproductive Medicine and Endoscopy Sugiyama Clinic Marunouchi 1-6-2 Marunouchi, Chiyoda-ku 100-0005 Tokyo Japan.
Reprod Med Biol. 2013 Apr 17;12(3):105-110. doi: 10.1007/s12522-013-0148-y. eCollection 2013 Jul.
The purpose of this study was to investigate how many oocytes are needed to achieve an adequate pregnancy rate per 1 oocyte retrieval cycle in mild ovarian stimulation.
This protocol consisted of clomiphene citrate and recombinant-follicle-stimulating hormone injection without a gonadotropin-releasing hormone-antagonist. From January 2009 through December 2010, there were 1,227 women who underwent assisted reproductive technologies treatment with mild stimulation at the Sugiyama Clinic. The overall pregnancy rate per single oocyte retrieval cycle was evaluated using both fresh and cryopreserved-and-thawed embryos according to the retrieved oocyte number.
According to the retrieved oocyte number, a total of 1,227 cycles were divided into 4 groups: group A (the oocyte number <4; 433 cycles), group B (the oocyte number = 4, 5; 317 cycles), group C (the oocyte number = 6, 7; 206 cycles), and group D (the oocyte number ≥8; 271 cycles). The overall pregnancy rates for groups A, B, C, and D were 22.2, 42.9, 52.4, and 56.0 %, respectively, the rates for groups C and D were significantly higher than that for group A ( < 0.01).
The optimal number of retrieved oocytes proved to be between 6 and 7 for the patients who received our milder stimulation protocol and experienced no reduction in their overall pregnancy rate.
本研究旨在探讨在轻度卵巢刺激的每个取卵周期中，需要多少个卵母细胞才能达到足够的妊娠率。
该方案包括使用枸橼酸氯米芬和重组促卵泡激素注射，不使用促性腺激素释放激素拮抗剂。2009年1月至2010年12月，有1227名妇女在杉山诊所接受了轻度刺激的辅助生殖技术治疗。根据取到的卵母细胞数量，使用新鲜胚胎和冷冻解冻胚胎评估每个取卵周期的总体妊娠率。
根据取到的卵母细胞数量，1227个周期共分为4组：A组（卵母细胞数量<4；433个周期），B组（卵母细胞数量=4、5；317个周期），C组（卵母细胞数量=6、7；206个周期），D组（卵母细胞数量≥8；271个周期）。A、B、C、D组的总体妊娠率分别为22.2%、42.9%、52.4%和56.0%，C组和D组的妊娠率显著高于A组（<0.01）。
对于接受我们较温和刺激方案且总体妊娠率未降低的患者，取到的最佳卵母细胞数量为6至7个。
