Nakagawa Koji, Kuroda Keiji, Sugiyama Rikikazu
Center for Reproductive Medicine and Implantation Research Sugiyama Clinic Shinjuku Tokyo Japan.
Reprod Med Biol. 2018 Nov 14;18(1):27-33. doi: 10.1002/rmb2.12240. eCollection 2019 Jan.
An ever-increasing number of women in our country with advanced maternal age are choosing to achieve pregnancy. This means effective strategies are needed for infertile patients. Questions arise, however, concerning the need for ovarian stimulation, and, if so, whether intracytoplasmic sperm injection (ICSI) is better than conventional insemination for those women who may have only one mature oocyte.
We evaluated our data to answer these questions. Herein, we also introduce our strategy for patients who show unsynchronized follicular growth.
Ovarian stimulation in ART treatment for patients with advanced maternal age has resulted in the achievement of higher pregnancy rates, and therefore, this form of stimulation is often selected. Based on our data, ICSI as an insemination procedure has not improved clinical pregnancy rates compared with conventional insemination and has actually decreased the clinical pregnancy rates.
In this article, we reviewed and compared the protocols and strategies that are available to increase the number of developed embryos for the patients with advanced maternal age. We hope that this review will be helpful for both patients and clinicians.
我国高龄孕产妇的数量日益增加，她们选择怀孕。这意味着需要为不孕患者制定有效的策略。然而，关于是否需要进行卵巢刺激，以及如果需要，对于那些可能只有一个成熟卵母细胞的女性，卵胞浆内单精子注射（ICSI）是否优于传统授精，出现了一些问题。
我们评估了我们的数据以回答这些问题。在此，我们还介绍了针对卵泡生长不同步患者的策略。
对于高龄孕产妇，辅助生殖技术（ART）治疗中的卵巢刺激已实现了更高的妊娠率，因此，这种刺激形式常被选用。根据我们的数据，作为一种授精程序，ICSI与传统授精相比并未提高临床妊娠率，实际上还降低了临床妊娠率。
在本文中，我们回顾并比较了可用于增加高龄孕产妇发育胚胎数量的方案和策略。我们希望这一综述对患者和临床医生都有所帮助。
