胚胎植入过程中的子宫容受性及胚胎-子宫相互作用：来自小鼠的经验教训
Uterine receptivity and embryo-uterine interactions in embryo implantation: lessons from mice.
作者信息
Egashira Mahiro, Hirota Yasushi
机构信息
Department of Obstetrics and Gynecology, Graduate School of Medicine University of Tokyo 113-8655 Tokyo Japan.
Laboratory of Animal Breeding, Graduate School of Agricultural and Life Sciences University of Tokyo 113-8657 Tokyo Japan.
出版信息
Reprod Med Biol. 2013 Jun 1;12(4):127-132. doi: 10.1007/s12522-013-0153-1. eCollection 2013 Oct.
Abstract
Implantation is a process of the first feto-maternal encounter in the uterus. A competent blastocyst and a receptive uterus are critical for successful implantation. For an acquisition of uterine receptivity, the following conditions need to be satisfied in the uterine environments: the endometrial preparation with stromal proliferation and epithelial differentiation in the pre-receptive phase and proper interactions between the uterus and blastocyst later in the phase. Focusing on these points and primarily referring to the mouse in vivo evidence, this review article has shown detailed molecular mechanisms for successful implantation.
摘要
着床是胚胎与母体在子宫内首次接触的过程。有活力的囊胚和具备容受性的子宫是成功着床的关键。为了获得子宫容受性，子宫环境需要满足以下条件：在容受前期进行子宫内膜准备，包括基质增殖和上皮分化，以及在此阶段后期子宫与囊胚之间的适当相互作用。围绕这些要点，并主要参考小鼠体内的证据，这篇综述文章展示了成功着床的详细分子机制。
相似文献
1
Uterine receptivity and embryo-uterine interactions in embryo implantation: lessons from mice.胚胎植入过程中的子宫容受性及胚胎-子宫相互作用：来自小鼠的经验教训
Reprod Med Biol. 2013 Jun 1;12(4):127-132. doi: 10.1007/s12522-013-0153-1. eCollection 2013 Oct.
2
Molecular and cellular events during blastocyst implantation in the receptive uterus: clues from mouse models.着床期子宫内胚泡植入过程中的分子和细胞事件：来自小鼠模型的线索
J Reprod Dev. 2017 Oct 18;63(5):445-454. doi: 10.1262/jrd.2017-047. Epub 2017 Jun 22.
3
The endometrial transcriptome transition preceding receptivity to embryo implantation in mice.在小鼠胚胎着床接受能力之前，子宫内膜转录组的转变。
BMC Genomics. 2023 Oct 4;24(1):590. doi: 10.1186/s12864-023-09698-3.
4
Steroids modulate the expression of alpha4 integrin in mouse blastocysts and uterus during implantation.类固醇在植入过程中调节小鼠胚泡和子宫中α4整合素的表达。
Biol Reprod. 2002 Jun;66(6):1784-9. doi: 10.1095/biolreprod66.6.1784.
5
Molecular and cellular events involved in the completion of blastocyst implantation.与囊胚着床完成相关的分子和细胞事件。
Reprod Med Biol. 2015 Aug 15;15(2):53-58. doi: 10.1007/s12522-015-0222-8. eCollection 2016 Apr.
6
Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation.辅助伴侣蛋白亲免素FKBP52对胚胎着床时的子宫容受性至关重要。
Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14326-31. doi: 10.1073/pnas.0505775102. Epub 2005 Sep 21.
7
Deciphering mouse uterine receptivity for embryo implantation at single-cell resolution.单细胞分辨率解析小鼠子宫对胚胎植入的接受性。
Cell Prolif. 2021 Nov;54(11):e13128. doi: 10.1111/cpr.13128. Epub 2021 Sep 23.
8
Particular functions of estrogen and progesterone in establishment of uterine receptivity and embryo implantation.雌激素和孕激素在建立子宫容受性和胚胎着床中的特定作用。
Histol Histopathol. 2010 Sep;25(9):1215-28. doi: 10.14670/HH-25.1215.
9
Uterine receptivity, embryo attachment, and embryo invasion: Multistep processes in embryo implantation.子宫容受性、胚胎黏附与胚胎侵入：胚胎着床的多步骤过程
Reprod Med Biol. 2019 May 24;18(3):234-240. doi: 10.1002/rmb2.12280. eCollection 2019 Jul.
10
The uterus is a potential site for anandamide synthesis and hydrolysis: differential profiles of anandamide synthase and hydrolase activities in the mouse uterus during the periimplantation period.子宫是花生四烯乙醇胺合成与水解的潜在部位：着床前期小鼠子宫中花生四烯乙醇胺合酶和水解酶活性的差异概况。
Mol Reprod Dev. 1996 Oct;45(2):183-92. doi: 10.1002/(SICI)1098-2795(199610)45:2<183::AID-MRD11>3.0.CO;2-2.
引用本文的文献
1
Do NGF and LPS Interact Synergistically to Modulate Inflammation in Sheep Endometrial Epithelial Cells?神经生长因子（NGF）和脂多糖（LPS）是否协同作用以调节绵羊子宫内膜上皮细胞中的炎症？
Int J Mol Sci. 2025 Jul 17;26(14):6862. doi: 10.3390/ijms26146862.
2
The Autocrine Impact of Nerve Growth Factor on Sheep Uterine Epithelial Cells.神经生长因子对绵羊子宫上皮细胞的自分泌影响。
Cells. 2025 Jan 31;14(3):208. doi: 10.3390/cells14030208.
3
Molecular and cellular regulators of embryo implantation and their application in improving the implantation potential of IVF-derived blastocysts.胚胎着床的分子和细胞调节因子及其在提高体外受精囊胚着床潜能中的应用。
Reprod Med Biol. 2025 Jan 24;24(1):e12633. doi: 10.1002/rmb2.12633. eCollection 2025 Jan-Dec.
4
Establishment of an In Vitro Embryo-Endometrium Model Using Alginate-Embedded Mouse Embryos and Human Embryoid Body.利用海藻酸盐包埋的小鼠胚胎和人胚状体建立体外胚胎-子宫内膜模型
Tissue Eng Regen Med. 2025 Jan;22(1):77-89. doi: 10.1007/s13770-024-00682-w. Epub 2024 Nov 29.
5
Gene expression profile analysis of subregions of the adult female reproductive tract in the brown anole, Anolis sagrei.棕色安乐蜥（安乐蜥属）成年雌性生殖道亚区域的基因表达谱分析。
Reproduction. 2025 Jan 11;169(2). doi: 10.1530/REP-24-0062. Print 2024 Feb 1.
6
Estrogen and Progesterone Receptors Are Dysregulated at the BPH/5 Mouse Preeclamptic-Like Maternal-Fetal Interface.雌激素和孕激素受体在BPH/5小鼠子痫前期样母胎界面处失调。
Biology (Basel). 2024 Mar 16;13(3):192. doi: 10.3390/biology13030192.
7
Extracellular Vesicles Secreted by Pre-Hatching Bovine Embryos Produced In Vitro and In Vivo Alter the Expression of IFNtau-Stimulated Genes in Bovine Endometrial Cells.体外和体内培养的牛胚胎孵化前分泌的细胞外囊泡改变了牛子宫内膜细胞中 IFNtau 刺激基因的表达。
Int J Mol Sci. 2023 Apr 18;24(8):7438. doi: 10.3390/ijms24087438.
8
Estrogen Actions in Placental Vascular Morphogenesis and Spiral Artery Remodeling: A Comparative View between Humans and Mice.雌激素在胎盘血管形态发生和螺旋动脉重塑中的作用：人与小鼠的比较观点。
Cells. 2023 Feb 14;12(4):620. doi: 10.3390/cells12040620.
9
Distinguish Characters of Luminal and Glandular Epithelium from Mouse Uterus Using a Novel Enzyme-Based Separation Method.利用新型酶基分离方法区分小鼠子宫腔上皮和腺体上皮的特征。
Reprod Sci. 2023 Jun;30(6):1867-1877. doi: 10.1007/s43032-022-01154-z. Epub 2022 Dec 29.
10
Dynamic Changes of Gene Expression in Mouse Mural Trophectoderm Regulated by During Implantation.着床期间由[具体因素]调控的小鼠壁滋养外胚层基因表达的动态变化
Front Cell Dev Biol. 2022 Aug 16;10:945241. doi: 10.3389/fcell.2022.945241. eCollection 2022.
本文引用的文献
1
Mechanisms of implantation: strategies for successful pregnancy.着床机制：成功妊娠的策略。
Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012.
2
Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence.雌激素依赖性子宫分泌骨桥蛋白激活囊胚黏附能力。
PLoS One. 2012;7(11):e48933. doi: 10.1371/journal.pone.0048933. Epub 2012 Nov 9.
3
Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity.条件性敲除子宫内 Msx 同源盒基因通过改变子宫容受性抑制胚胎着床。
Dev Cell. 2011 Dec 13;21(6):1014-25. doi: 10.1016/j.devcel.2011.09.010. Epub 2011 Nov 17.
4
Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice.子宫特异性 p53 缺失导致子宫早衰并促进小鼠早产。
J Clin Invest. 2010 Mar;120(3):803-15. doi: 10.1172/JCI40051.
5
A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells.LIF信号通路的并联电路维持小鼠胚胎干细胞的多能性。
Nature. 2009 Jul 2;460(7251):118-22. doi: 10.1038/nature08113.
6
Secreted phosphoprotein 1 (SPP1, osteopontin) binds to integrin alpha v beta 6 on porcine trophectoderm cells and integrin alpha v beta 3 on uterine luminal epithelial cells, and promotes trophectoderm cell adhesion and migration.分泌型磷蛋白1（SPP1，骨桥蛋白）与猪滋养外胚层细胞上的整合素αvβ6以及子宫腔上皮细胞上的整合素αvβ3结合，并促进滋养外胚层细胞的黏附和迁移。
Biol Reprod. 2009 Nov;81(5):814-25. doi: 10.1095/biolreprod.109.078600. Epub 2009 Jul 1.
7
HB-EGF: a unique mediator of embryo-uterine interactions during implantation.肝素结合表皮生长因子：着床期间胚胎与子宫相互作用的独特介质。
Exp Cell Res. 2009 Feb 15;315(4):619-26. doi: 10.1016/j.yexcr.2008.07.025. Epub 2008 Aug 3.
8
Maternal heparin-binding-EGF deficiency limits pregnancy success in mice.母体肝素结合表皮生长因子缺乏会限制小鼠的妊娠成功率。
Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18315-20. doi: 10.1073/pnas.0707909104. Epub 2007 Nov 6.
9
Control of osteopontin signaling and function by post-translational phosphorylation and protein folding.通过翻译后磷酸化和蛋白质折叠对骨桥蛋白信号传导及功能的调控
J Cell Biochem. 2007 Nov 1;102(4):912-24. doi: 10.1002/jcb.21558.
10
FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific.FKBP52 缺乏导致的子宫孕激素抵抗具有遗传背景和妊娠阶段特异性。
J Clin Invest. 2007 Jul;117(7):1824-34. doi: 10.1172/JCI31622.
Zotero 插件