Egashira Mahiro, Hirota Yasushi
Department of Obstetrics and Gynecology, Graduate School of Medicine University of Tokyo 113-8655 Tokyo Japan.
Laboratory of Animal Breeding, Graduate School of Agricultural and Life Sciences University of Tokyo 113-8657 Tokyo Japan.
Reprod Med Biol. 2013 Jun 1;12(4):127-132. doi: 10.1007/s12522-013-0153-1. eCollection 2013 Oct.
Implantation is a process of the first feto-maternal encounter in the uterus. A competent blastocyst and a receptive uterus are critical for successful implantation. For an acquisition of uterine receptivity, the following conditions need to be satisfied in the uterine environments: the endometrial preparation with stromal proliferation and epithelial differentiation in the pre-receptive phase and proper interactions between the uterus and blastocyst later in the phase. Focusing on these points and primarily referring to the mouse in vivo evidence, this review article has shown detailed molecular mechanisms for successful implantation.
着床是胚胎与母体在子宫内首次接触的过程。有活力的囊胚和具备容受性的子宫是成功着床的关键。为了获得子宫容受性，子宫环境需要满足以下条件：在容受前期进行子宫内膜准备，包括基质增殖和上皮分化，以及在此阶段后期子宫与囊胚之间的适当相互作用。围绕这些要点，并主要参考小鼠体内的证据，这篇综述文章展示了成功着床的详细分子机制。
