Doshida Masakazu, Nakajo Yukiko, Toya Mayumi, Kyono Koichi
Kyono ART Clinic 1-1-1-3F, Honcho, Aobaku 980-0014 Sendai Miyagi Japan.
Reprod Med Biol. 2013 Jun 5;12(4):187-191. doi: 10.1007/s12522-013-0154-0. eCollection 2013 Oct.
To report a live birth from vitrified-warmed oocytes for a Philadelphia chromosome-positive acute lymphoid leukemia (Ph-ALL) patient.
A 20-year-old single woman with Ph-ALL requested oocyte cryopreservation at a private fertility clinic using assisted reproduction technology (ART). In cases of leukemia, there is a very short time before chemotherapy, follwed shortly by total body irradiation (TBI), and although she had already received the chemotherapy, ten oocytes were vitrified and stored for 59 months before warming. Soon after the oocyte cryopreservation, she received TBI and bone marrow transplant (BMT). During the storage, a magnitude 9.0 earthquake occurred making oocyte transport necessary. The embryo transfer was planned in a hormone replacement cycle, and intracytoplasmic sperm injection (ICSI) was performed on the vitrified-warmed oocytes. On day 3, two embryos were transferred.
The patient became pregnant and delivered a healthy girl after ICSI using vitrified-warmed oocytes.
Oocyte cryopreservation is the best option for fertility preservation of young single women with leukemia. Oncologists and gynecologists who conduct ART should cooperate to improve the quality of life of cancer patients.
报告一例通过玻璃化冷冻复苏卵母细胞实现活产的费城染色体阳性急性淋巴细胞白血病（Ph-ALL）患者。
一名20岁的单身Ph-ALL女性患者在一家私立生育诊所请求使用辅助生殖技术（ART）进行卵母细胞冷冻保存。对于白血病患者，化疗前时间非常短，随后很快进行全身照射（TBI），尽管她已经接受了化疗，但仍有10枚卵母细胞被玻璃化冷冻并保存了59个月后复苏。卵母细胞冷冻保存后不久，她接受了TBI和骨髓移植（BMT）。在保存期间，发生了9.0级地震，使得卵母细胞运输成为必要。计划在激素替代周期进行胚胎移植，并对玻璃化冷冻复苏的卵母细胞进行卵胞浆内单精子注射（ICSI）。在第3天，移植了2枚胚胎。
该患者在使用玻璃化冷冻复苏卵母细胞进行ICSI后怀孕并产下一名健康女婴。
卵母细胞冷冻保存是年轻单身白血病女性生育力保存的最佳选择。开展ART的肿瘤学家和妇科医生应合作以提高癌症患者的生活质量。
