Bataineh Hameed N, Bataineh Ziad M, Daradka Haytham
Department of Physiology and.
Department of Anatomy, Faculty of Medicine, Jordan University of Science and Technology, Irbid, and.
Reprod Med Biol. 2007 Aug 6;6(3):179-183. doi: 10.1111/j.1447-0578.2007.00183.x. eCollection 2007 Sep.
The objective of this study was to characterize the adverse effects of industrial metal salts during the early stages of pregnancy. Successfully mated female rats were exposed to the following metal salts via intragastric intubation; manganese sulfate, lead acetate, aluminum chloride, ferrous chloride and ferric chloride in doses of 50 mg/kg body weight and chromium chloride and potassium dichromate in doses of 25 mg/kg body weight on days l-3 or 4-6 of pregnancy. Female rats were killed on day 20 of gestation and the pregnancy outcome was determined. The administration of manganese sulfate, chromium chloride, potassium dichromate and ferric chloride to female rats on days 1-3 of pregnancy caused pregnancy failure. However, the administration of manganese sulfate and potassium dichromate reduced the number of implantations. The administration of manganese sulfate, potassium dichromate and ferric chloride reduced the number of viable fetuses. The total number of resorptions increased in the lead acetate, aluminum chloride, ferrous chloride and ferric chloride exposed groups. In contrast, the administration of manganese sulfate, aluminum chloride and ferric chloride on days 4-6 of pregnancy caused pregnancy failure. However, the administration of ferric chloride reduced the number of implantations. The administration of manganese sulfate, aluminum chloride, potassium dichromate, ferrous chloride and ferric chloride reduced the number of viable fetuses. The total number of resorptions increased in the manganese sulfate, lead acetate, aluminum chloride, potassium dichromate, ferrous chloride and ferric chloride exposed groups. This work demonstrates that the short-term exposure of female rats to industrial metal salts during the early stages of gestation would cause failure of pregnancy and produce fetotoxic or fetal resorptive potentials. (Reprod Med Biol 2007; : 179-183).
本研究的目的是描述妊娠早期工业金属盐的不良反应。成功交配的雌性大鼠通过胃内插管暴露于以下金属盐：硫酸锰、醋酸铅、氯化铝、氯化亚铁和氯化铁，剂量为50毫克/千克体重；氯化铬和重铬酸钾，剂量为25毫克/千克体重，在妊娠第1 - 3天或第4 - 6天给药。雌性大鼠在妊娠第20天处死并确定妊娠结局。在妊娠第1 - 3天给雌性大鼠施用硫酸锰、氯化铬、重铬酸钾和氯化铁会导致妊娠失败。然而，施用硫酸锰和重铬酸钾会减少着床数量。施用硫酸锰、重铬酸钾和氯化铁会减少活胎数量。在醋酸铅、氯化铝、氯化亚铁和氯化铁暴露组中，吸收总数增加。相比之下，在妊娠第4 - 6天施用硫酸锰、氯化铝和氯化铁会导致妊娠失败。然而，施用氯化铁会减少着床数量。施用硫酸锰、氯化铝、重铬酸钾、氯化亚铁和氯化铁会减少活胎数量。在硫酸锰、醋酸铅、氯化铝、重铬酸钾、氯化亚铁和氯化铁暴露组中，吸收总数增加。这项工作表明，雌性大鼠在妊娠早期短期暴露于工业金属盐会导致妊娠失败，并产生胎儿毒性或胎儿吸收潜能。（《生殖医学与生物学》2007年；：179 - 183）
