Anane R, Bonini M, Creppy E E
Laboratory of Toxicology and Applied Hygiene, Faculty of Pharmaceutical Sciences, University Bordeaux 2, France.
Hum Exp Toxicol. 1997 Sep;16(9):501-4. doi: 10.1177/096032719701600904.
Aluminum is present in tap water, antiperspirants and cosmetics up to 20%. Teratogenicity of aluminium was clearly identified after per os or intravenous administration. Malformations and other alterations by aluminium intoxication were evaluated in fetus. In the present study, we investigated the possible transplacental passage of aluminium and its accumulation in the tissue after cutaneous uptake. Female Swiss mice received aluminium chloride by cutaneous way (0.4 micrograms/day) during 20 days of gestation. The samples were assayed for aluminium quantification by graphite furnace atomic absorption with Zeeman correction. This treatment led to an increase of aluminum in maternal and fetus samples (serum, amniotic fluid and organs) as compared to controls.
自来水中、止汗剂及化妆品中铝的含量高达20%。经口或静脉给药后，铝的致畸性已得到明确证实。对胎儿铝中毒所致的畸形及其他改变进行了评估。在本研究中，我们调查了铝经皮肤吸收后经胎盘转运的可能性及其在组织中的蓄积情况。妊娠20天期间，雌性瑞士小鼠经皮肤途径给予氯化铝（0.4微克/天）。采用带塞曼校正的石墨炉原子吸收法对样品进行铝含量测定。与对照组相比，该处理导致母体及胎儿样本（血清、羊水及器官）中的铝含量增加。
