Zhu Wei, Heil Daniel P
Department of Health and Human Development, Montana State University, Bozeman, MT, 59717, USA; Department of Nutrition, Shanghai Institute of Health Sciences, Shanghai, 201318, China.
Department of Health and Human Development, Montana State University, Bozeman, MT, 59717, USA.
Diabetes Metab Syndr. 2018 Sep;12(5):727-732. doi: 10.1016/j.dsx.2018.04.010. Epub 2018 Apr 17.
This study investigated the associations of vitamin D status (i.e., serum 25(OH)D concentration) with markers of metabolic health and metabolic syndrome (MS), as well as possible gender differences in these associations, with metabolic syndrome (MS) for a sample from Shanghai, China.
Demographic and anthropometric data, as well as 25-hydroxyvitamin D (serum 25(OH)D), blood glucose, and lipid concentrations were obtained for 508 urban residents aged 19-70 years. After grouping into tertiles according to their serum 25(OH)D concentrations, linear and logistic regressions were used to evaluate associations between serum 25(OH)D concentration and risk factors for MS across tertiles.
A 1 ng/mL increase in 25(OH)D was associated with a significant decrease in total cholesterol by 0.25 mmol/L [95% CI: (-0.44, -0.05); P = 0.014] for the third tertile, with reference to the first tertile. Also, 1 ng/mL increase in 25(OH)D was associated with a significant decrease in LDL by 0.18 mmol/L [95% CI: (-0.35, -0.02); P = 0.026] for the third tertile. In addition, participants in the third tertile had a 54% reduction in the OR for MS [95% CI: (-1.10,- 0.02), P = 0.041]. Lastly, while there was no gender difference in vitamin D deficiency status, the non-MS women had significantly higher 25(OH)D level than those with MS (30.1 ± 5.8 vs. 28.5 ± 5.9 ng/mL, P = 0.035), while no such difference was observed for men.
Higher serum 25(OH)D concentration was associated with a better metabolic profile and thus a lower risk for developing MS in urban Shanghai residents of China.
本研究调查了维生素D状态（即血清25(OH)D浓度）与代谢健康和代谢综合征（MS）标志物之间的关联，以及中国上海一个样本中这些关联可能存在的性别差异与代谢综合征（MS）的关系。
获取了508名年龄在19 - 70岁的城市居民的人口统计学和人体测量数据，以及25 - 羟基维生素D（血清25(OH)D）、血糖和血脂浓度。根据血清25(OH)D浓度分为三个三分位数组后，采用线性回归和逻辑回归评估血清25(OH)D浓度与各三分位数组中MS危险因素之间的关联。
与第一个三分位数组相比，第三个三分位数组中25(OH)D每增加1 ng/mL，总胆固醇显著降低0.25 mmol/L [95%置信区间：(-0.44, -0.05)；P = 0.014]。此外，第三个三分位数组中25(OH)D每增加1 ng/mL，低密度脂蛋白显著降低0.18 mmol/L [95%置信区间：(-0.35, -0.02)；P = 0.026]。此外，第三个三分位数组参与者患MS的比值比降低了54% [95%置信区间：(-1.10, -0. , P = 0.041]。最后，虽然维生素D缺乏状态没有性别差异，但非MS女性的25(OH)D水平显著高于患有MS的女性（30.1±5.8 vs. 28.5±5.9 ng/mL，P = 0.035），而男性未观察到这种差异。
在中国上海城市居民中，较高的血清25(OH)D浓度与更好的代谢状况相关，因此患MS的风险较低。
