Yu Xiaodan, Wang Weiye, Wei Zhenzhen, Ouyang Fengxiu, Huang Lisu, Wang Xia, Zhao Yanjun, Zhang Huijuan, Zhang Jun
MOE-Shanghai Key Lab of Children's Environmental Health, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Departments of Pathology and Bio-Bank, the International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.
Nutrients. 2014 Dec 4;6(12):5600-10. doi: 10.3390/nu6125600.
With the increasing recognition of the importance of the non-skeletal effects of vitamin D (VitD), more and more attention has been drawn to VitD status in early life. However, the VitD status of newborns and factors that influence VitD levels in Shanghai, China, remain unclear. A total of 1030 pregnant women were selected from two hospitals in Shanghai, one of the largest cities in China located at 31 degrees north latitude. Umbilical cord serum concentrations of 25-hydroxy vitamin D [25(OH)D] were measured by LC-MS-MS, and questionnaires were used to collect information. The median cord serum 25(OH)D concentration was 22.4 ng/mL; the concentration lower than 20 ng/mL accounted for 36.3% of the participants, and the concentration lower than 30 ng/mL for 84.1%. A multivariable logistic regression model showed that the determinants of low 25(OH)D status were being born during autumn or winter months and a lack of VitD-related multivitamin supplementation. The relative risk was 1.7 for both autumn (95% CI, 1.1-2.6) and winter (95% CI, 1.1-2.5) births (p < 0.05). VitD-related multivitamin supplementation more than once a day during pregnancy reduced the risk of VitD deficiency [adjusted OR (aOR) = 0.6, 95% CI (0.45-1.0) for VitD supplementation] (p < 0.05). VitD deficiency and insufficiency are common in newborns in Shanghai, China, and are independently associated with season and VitD supplementation. Our findings may assist future efforts to correct low levels of 25(OH)D in Shanghai mothers and their newborn children.
随着对维生素D（VitD）非骨骼效应重要性的认识不断提高，生命早期的VitD状况越来越受到关注。然而，中国上海新生儿的VitD状况以及影响VitD水平的因素仍不清楚。从上海的两家医院选取了1030名孕妇，上海是中国最大的城市之一，位于北纬31度。采用液相色谱-串联质谱法测定脐带血清25-羟基维生素D[25(OH)D]浓度，并通过问卷调查收集信息。脐带血清25(OH)D浓度中位数为22.4 ng/mL；低于20 ng/mL的浓度占参与者的36.3%，低于30 ng/mL的浓度占84.1%。多变量逻辑回归模型显示，25(OH)D水平低的决定因素是在秋季或冬季出生以及缺乏与VitD相关的多种维生素补充剂。秋季（95%CI，1.1 - 2.6）和冬季（95%CI，1.1 - 2.5）出生的相对风险均为1.7（p < 0.05）。孕期每天服用一次以上与VitD相关的多种维生素可降低VitD缺乏的风险[补充VitD的调整比值比（aOR）= 0.6，95%CI（0.45 - 1.0）]（p < 0.05）。在中国上海，新生儿VitD缺乏和不足很常见，且与季节和VitD补充独立相关。我们的研究结果可能有助于未来纠正上海母亲及其新生儿低水平25(OH)D的工作。
