Department of Internal Medicine and Cardiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Department of Medicine and Surgery, University of Milan-Bicocca, Meda, Italy.
J Clin Hypertens (Greenwich). 2018 Jun;20(6):1001-1007. doi: 10.1111/jch.13300. Epub 2018 Apr 27.
The aim of the present study is to investigate the predictive value of pulse pressure (PP) on cardiovascular events in the general population and in both sexes, separately. The study involved 2045 participants from the PAMELA study who underwent 24-hour ambulatory blood pressure (BP) monitoring. The participants were followed from the initial medical visit for a time interval of 137 ± 23 months. It was found that office, home, and 24-hour blood pressures were significantly higher in the individuals who experienced cardiovascular (CV) events. Office, 24-hour, and daytime PP were independent predictors of CV events after adjustment for main demographic and clinical parameters in the whole study population. Nighttime PP was an additional independent predictor in men. In conclusion, PP represents an important predictor of cardiovascular events in the general population, particularly among men. Daytime and 24-hour PP have greater predictive importance than nighttime PP in the general population.
本研究旨在探讨脉压（PP）对一般人群及不同性别人群心血管事件的预测价值。该研究纳入了 PAMELA 研究中的 2045 名参与者，他们接受了 24 小时动态血压监测。参与者从首次就诊开始随访，随访时间间隔为 137 ± 23 个月。研究发现，发生心血管（CV）事件的个体的诊室、家庭和 24 小时血压显著升高。在校正了主要人口统计学和临床参数后，办公室、24 小时和日间 PP 是整个研究人群中 CV 事件的独立预测因子。夜间 PP 是男性的另一个独立预测因子。总之，PP 是一般人群心血管事件的重要预测因子，尤其是男性。日间和 24 小时 PP 比一般人群中的夜间 PP 具有更大的预测重要性。
