从 Polynesian 海绵中提取的具有生物活性的溴代酪氨酸衍生生物碱
Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge .
机构信息
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, University Paris-Sud, University of Paris-Saclay, 1, Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France.
Organic Chemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt.
出版信息
Mar Drugs. 2018 Apr 27;16(5):146. doi: 10.3390/md16050146.
Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids ⁻ from the Polynesian sponge , along with known major compound psammaplysene D (), ,-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D () displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC values of 0.7 μM and 1.3 μM, respectively.
在此，我们描述了从波利尼西亚海绵中分离和光谱鉴定的八种新的四溴酪氨酸生物碱，以及已知的主要化合物 psammaplysene D (),,-二甲二溴酪胺、5-羟基氧杂蒽尿酸和氧杂蒽尿酸。对一些分离的代谢物进行了细胞毒性和乙酰胆碱酯酶抑制活性评价。它们对 KB 癌细胞系表现出中等的抗增殖活性，但 psammaplysene D () 表现出显著的细胞毒性和乙酰胆碱酯酶抑制活性，IC 值分别为 0.7 μM 和 1.3 μM。
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