Nail Disease Center, Cannes, France.
Dermatopathology 75019, Paris, France.
J Eur Acad Dermatol Venereol. 2018 Sep;32(9):1608-1613. doi: 10.1111/jdv.15017. Epub 2018 Jun 7.
Benign subungual proliferation of the distal nail matrix and bed such as longitudinal keratosis, seborrhoeic keratosis or onychocytic matricoma should belong to a single spectrum of diseases.
This article intends to demonstrate clinically and histologically the different facets of Nail unit longitudinal acanthoma.
We report three new cases that present as a longitudinal melanonychia with thickening of the nail plate in two of them and as leukoxanthonychia in the third one. We compared them with the two original cases we described in 1999, reminiscent of seborrhoeic keratosis and all the new cases published since then.
We therefore consider that all these tumours belong to a single spectrum of diseases, we have called 'nail unit longitudinal acanthoma' which describes a histopathological process. The distinct clinical features of these tumours, melanonychia or leukoxanthonychia may be linked to their variable anatomic locations in different zones of the nail unit.
良性甲远端基质和床的下增殖，如纵向角化病、脂溢性角化病或甲母质瘤细胞增多症，应属于单一疾病谱。
本文旨在从临床和组织学方面展示甲单位纵向棘皮瘤的不同方面。
我们报告了三个新病例，其中两个表现为纵向黑素甲，其中两个表现为甲增厚，第三个表现为白甲。我们将它们与我们在 1999 年描述的两个原发病例进行了比较，类似于脂溢性角化病，以及此后所有新发表的病例。
因此，我们认为所有这些肿瘤都属于单一疾病谱，我们称之为“甲单位纵向棘皮瘤”，它描述了一种组织病理学过程。这些肿瘤的不同临床特征，黑素甲或白甲，可能与其在甲单位不同区域的不同解剖位置有关。
