Rea Domenica, Coppola Giovanni, Palma Giuseppe, Barbieri Antonio, Luciano Antonio, Del Prete Paola, Rossetti Sabrina, Berretta Massimiliano, Facchini Gaetano, Perdonà Sisto, Turco Maria Caterina, Arra Claudio
S.S.D Sperimentazione Animale, Istituto Nazionale Tumori, IRCCS, "Fondazione G. Pascale", Naples, Italy.
Direzione Scientifica, Istituto Nazionale Tumori, IRCCS, "Fondazione G. Pascale", Naples, Italy.
Oncotarget. 2018 Apr 3;9(25):17915-17927. doi: 10.18632/oncotarget.24681.
Gut microbiota, a group of 10 bacteria, eukaryotes and virus living in gastrointestinal tract, is crucial for many physiological processes in particular plays an important role in inflammatory and immune reactions. Several internal and external factors can influence this population, and shifts in their composition, have been demonstrated to contribute and affect different diseases. During dysbiosis several bacteria related to inflammation, one of the most necessary factors in carcinogenesis; it has been shown that some bacterial strains through deregulation of different signals/pathways may affect tumor development through the production of many factors. Gut microbiota might be considered as a holistic hub point for cancer development: direct and indirect involvements have been studying in several neoplasms such as colon rectal cancer, hepatocellular carcinoma and breast cancer. This review discuss over the evidence of crosstalk between gut microbiota and cancer, its ability to modulate chemotherapy, radiotherapy and immunotherapy, and the possibility that the intestinal microbial is a new target for therapeutic approaches to improve the prognosis and quality of life of cancer patients.
肠道微生物群是生活在胃肠道中的一组细菌、真核生物和病毒，对许多生理过程至关重要，尤其在炎症和免疫反应中发挥重要作用。几个内部和外部因素可以影响这一群体，并且已经证明其组成的变化会导致并影响不同的疾病。在生态失调期间，几种与炎症相关的细菌是致癌过程中最必要的因素之一；已经表明，一些细菌菌株通过不同信号/途径的失调，可能通过产生多种因素影响肿瘤发展。肠道微生物群可能被视为癌症发展的一个整体枢纽点：在几种肿瘤如结直肠癌、肝细胞癌和乳腺癌中，已经对其直接和间接参与进行了研究。这篇综述讨论了肠道微生物群与癌症之间相互作用的证据、其调节化疗、放疗和免疫治疗的能力，以及肠道微生物成为改善癌症患者预后和生活质量治疗方法新靶点的可能性。
