Pelzer Elise, Gomez-Arango Luisa F, Barrett Helen L, Nitert Marloes Dekker
School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia; School of Medicine, The University of Queensland, Brisbane, Australia.
Placenta. 2017 Jun;54:30-37. doi: 10.1016/j.placenta.2016.12.003. Epub 2016 Dec 2.
Over the past decade, the role of the microbiome in regulating metabolism, immune function and behavior in humans has become apparent. It has become clear that the placenta is not a sterile organ, but rather has its own endogenous microbiome. The composition of the placental microbiome is distinct from that of the vagina and has been reported to resemble the oral microbiome. Compared to the gut microbiome, the placental microbiome exhibits limited microbial diversity. This review will focus on the current understanding of the placental microbiota in normal healthy pregnancy and also in disease states including preterm birth, chorioamnionitis and maternal conditions such as obesity, gestational diabetes mellitus and preeclampsia. Factors known to alter the composition of the placental microbiota will be discussed in the final part of this review.
在过去十年中，微生物群在调节人类新陈代谢、免疫功能和行为方面的作用已变得明显。很明显，胎盘不是一个无菌器官，而是有其自身的内源性微生物群。胎盘微生物群的组成与阴道不同，据报道类似于口腔微生物群。与肠道微生物群相比，胎盘微生物群的微生物多样性有限。本综述将聚焦于目前对正常健康妊娠以及包括早产、绒毛膜羊膜炎和肥胖、妊娠期糖尿病和子痫前期等母体疾病状态下胎盘微生物群的认识。已知会改变胎盘微生物群组成的因素将在本综述的最后部分进行讨论。
