使用含造影剂的光声成像技术对小鼠淋巴管进行可视化。
Visualization of murine lymph vessels using photoacoustic imaging with contrast agents.
作者信息
Nagaoka Ryo, Tabata Takuya, Yoshizawa Shin, Umemura Shin-Ichiro, Saijo Yoshifumi
机构信息
Biomedical Imaging Laboratory, Graduate School of Biomedical Engineering, Tohoku University, 6-6-05 Aramaki Aza Aoba, Aobaku, Sendai 980-8579, Japan.
Ultrasound Enhanced Nanomedicine Laboratory, Graduate School of Biomedical Engineering, Tohoku University, 6-6-05 Aramaki Aza Aoba, Aobaku, Sendai 980-8579, Japan.
出版信息
Photoacoustics. 2018 Jan 31;9:39-48. doi: 10.1016/j.pacs.2018.01.001. eCollection 2018 Mar.
Metastasis frequently occurs even in the early stage of breast cancer. This research studied the feasibility of using photoacoustic (PA) imaging for identifying metastasis in the lymph vessels of mice. The photoacoustic efficiency of various contrast agents was investigated, and the influence of scattered light was evaluated by using a lymph vessel phantom. The lymph vessels of mice were then visualized using the selected contrast agents: indocyanine green (ICG) and gold nanorods (AuNR). The attenuation of the PA imaging was -1.90 dB/mm, whereas that of the fluorescence imaging was -4.45 dB/mm. The results indicate the potential of identifying sentinel lymph nodes by using PA imaging with these contrast agents.
即使在乳腺癌早期也经常发生转移。本研究探讨了使用光声（PA）成像识别小鼠淋巴管转移的可行性。研究了各种造影剂的光声效率，并使用淋巴管模型评估了散射光的影响。然后使用选定的造影剂：吲哚菁绿（ICG）和金纳米棒（AuNR）对小鼠的淋巴管进行可视化。光声成像的衰减为-1.90 dB/mm，而荧光成像的衰减为-4.45 dB/mm。结果表明，使用这些造影剂通过光声成像识别前哨淋巴结具有潜力。
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