生物学与医学中活性氧的定义。
Defining ROS in Biology and Medicine.
作者信息
Li Robert, Jia Zhenquan, Trush Michael A
机构信息
Departments of Pharmacology and Pharmaceutical Sciences, Campbell University, Buies Creek, NC 27506, USA.
Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA.
出版信息
React Oxyg Species (Apex). 2016;1(1):9-21. doi: 10.20455/ros.2016.803.
Abstract
Utilization of molecular oxygen by aerobic organisms inevitably results in the formation of a number of oxygen-containing reactive species that are collectively known as reactive oxygen species (ROS). ROS play important roles in both physiology and pathophysiology of aerobic life. The field of 'ROS biology and medicine' deals with the involvement of ROS and related species in contemporary biology and medicine. The purpose of this article is to survey common terms and concepts in ROS biology and medicine. It also introduces the 'ROS paradigm' so as to provide a conceptual framework for understanding the rapidly evolving field of ROS biology and medicine.
摘要
需氧生物对分子氧的利用不可避免地会导致多种含氧化合物的形成，这些化合物统称为活性氧（ROS）。ROS在需氧生物的生理和病理生理过程中都发挥着重要作用。“ROS生物学与医学”领域研究ROS及相关物质在当代生物学和医学中的作用。本文旨在综述ROS生物学与医学中的常见术语和概念。同时还介绍了“ROS范式”，以便为理解迅速发展的ROS生物学与医学领域提供一个概念框架。
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