Lithgow Hannah Margaret, Florida-James Geraint, Leggate Melanie
Department of Sport and Exercise Science, School of Applied Sciences, Edinburgh Napier University, Edinburgh, United Kingdom.
Physiol Rep. 2018 May;6(9):e13684. doi: 10.14814/phy2.13684.
High-intensity intermittent training (HIIT) has been shown to reduce the risk of chronic conditions including the development of type 2 diabetes mellitus (T2DM). Independently, a low vitamin D status has also been linked to the prevalence of T2DM. The aim of this study was to investigate if there was a synergistic metabolic effect of HIIT and vitamin D supplementation on glycemic control. A total of 20 male and female participants (age, 34 ± 9 year; BMI, 31.4 ± 2.8 kg·m ) completed 6 weeks HIIT, and were randomized to ingest 100 μg·day of vitamin D or placebo. Response to an oral glucose tolerance test (OGTT) was determined at baseline and at 72 h postintervention. Glucose tolerance was improved as a result of the HIIT intervention, shown through a reduction in glucose and insulin concentrations during the OGTT, accompanied by a decrease in glucose (829 ± 110 to 786 ± 139 mmol·h ·L ; P = 0.043) and insulin (8101 ± 4755-7024 ± 4489 mU·h ·L ; P = 0.049) area under the curve (AUC). Supplementation increased 25-hydroxyvitamin D concentration by 120% to a sufficiency status (P < 0.001). However, the consumption of vitamin D seemed to attenuate the glucose response during an OGTT. Triglyceride content was lowered following the intervention (P = 0.025). There was no effect of the intervention on insulin sensitivity (IS) indices: ISI and HOMA-IR. Our findings demonstrate that HIIT improves glucose tolerance in nondiabetic overweight and obese adults; however vitamin D supplementation did not proffer any additional positive effects on the measured indices of metabolic health.
高强度间歇训练（HIIT）已被证明可降低包括2型糖尿病（T2DM）发病在内的慢性疾病风险。另外，维生素D水平低也与T2DM的患病率有关。本研究的目的是调查HIIT和补充维生素D对血糖控制是否具有协同代谢作用。共有20名男性和女性参与者（年龄34±9岁；体重指数31.4±2.8kg·m ）完成了6周的HIIT，并被随机分为每天摄入100μg维生素D或安慰剂组。在基线和干预后72小时测定口服葡萄糖耐量试验（OGTT）的反应。HIIT干预改善了葡萄糖耐量，这通过OGTT期间葡萄糖和胰岛素浓度的降低得以体现，同时葡萄糖曲线下面积（AUC）降低（829±110至786±139mmol·h·L ；P = 0.043），胰岛素AUC降低（8101±4755至7024±4489mU·h·L ；P = 0.049）。补充剂使25-羟基维生素D浓度提高了120%达到充足状态（P < 0.001）。然而，摄入维生素D似乎减弱了OGTT期间的葡萄糖反应。干预后甘油三酯含量降低（P = 0.025）。干预对胰岛素敏感性（IS）指标：胰岛素敏感指数（ISI）和稳态模型评估胰岛素抵抗（HOMA-IR）没有影响。我们的研究结果表明，HIIT可改善非糖尿病超重和肥胖成年人的葡萄糖耐量；然而，补充维生素D对所测量的代谢健康指标没有任何额外的积极影响。
