Department of Chemistry , University of Massachusetts Amherst , 710 North Pleasant Street , Amherst , Massachusetts 01003 , United States.
Chulabhorn International College of Medicine , Thammasat University , Pathum Thani 12120 , Thailand.
J Am Chem Soc. 2018 May 16;140(19):6176-6182. doi: 10.1021/jacs.8b03575. Epub 2018 May 4.
Infections caused by multidrug-resistant (MDR) bacteria are a rapidly growing threat to human health, in many cases exacerbated by their presence in biofilms. We report here a biocompatible oil-in-water cross-linked polymeric nanocomposite that degrades in the presence of physiologically relevant biomolecules. These degradable nanocomposites demonstrated broad-spectrum penetration and elimination of MDR bacteria, eliminating biofilms with no toxicity to cocultured mammalian fibroblast cells. Notably, serial passaging revealed that bacteria were unable to develop resistance toward these nanocomposites, highlighting the therapeutic promise of this platform.
由耐多药（MDR）细菌引起的感染对人类健康构成了日益严重的威胁，在许多情况下，其存在于生物膜中会使情况恶化。我们在这里报告一种生物相容的油包水交联聚合物纳米复合材料，它在存在生理相关生物分子的情况下会降解。这些可降解的纳米复合材料表现出广谱穿透和消除耐多药细菌的能力，消除生物膜，同时对共培养的哺乳动物成纤维细胞没有毒性。值得注意的是，连续传代表明细菌无法对这些纳米复合材料产生耐药性，这突出了该平台的治疗潜力。
