Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters: University Magna Græcia of Catanzaro, Viale Europa 88100 Catanzaro, Italy.
Expert Rev Anti Infect Ther. 2015 May;13(5):605-13. doi: 10.1586/14787210.2015.1023291. Epub 2015 Mar 8.
Chronic leg ulcers affect 1-2% of the general population and are related to increased morbidity and health costs. Staphylococcus aureus and Pseudomonas aeruginosa are the most common bacteria isolated from chronic wounds. They can express virulence factors and surface proteins affecting wound healing. The co-infection of S. aureus and P. aeruginosa is more virulent than single infection. In particular, S. aureus and P. aeruginosa have both intrinsic and acquired antibiotic resistance, making clinical management of infection a real challenge, particularly in patients with comorbidity. Therefore, a correct and prompt diagnosis of chronic wound infection requires a detailed knowledge of skin bacterial flora. This is a necessary prerequisite for tailored pharmacological treatment, improving symptoms, and reducing side effects and antibiotic resistance.
慢性腿部溃疡影响一般人群的 1-2%，并与发病率和健康成本增加有关。金黄色葡萄球菌和铜绿假单胞菌是从慢性伤口中分离出来的最常见细菌。它们可以表达影响伤口愈合的毒力因子和表面蛋白。金黄色葡萄球菌和铜绿假单胞菌的混合感染比单一感染更具毒性。特别是，金黄色葡萄球菌和铜绿假单胞菌都具有内在和获得性抗生素耐药性，这使得感染的临床管理成为一个真正的挑战，特别是对于合并症患者。因此，慢性伤口感染的正确和及时诊断需要对皮肤细菌菌群有详细的了解。这是针对特定药物治疗、改善症状和减少副作用和抗生素耐药性的必要前提。
