Mohammadi Vida, Dehghani Sirous, Askari Gholamreza
Department of Community Nutrition, Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Prev Med. 2017 May 11;8:33. doi: 10.4103/2008-7802.206138. eCollection 2017.
Although several animal and human studies have investigated the effect of alpha-lipoic acid (ALA) on blood pressure (BP), these findings are inconsistent. This systematic review of randomized clinical trials was conducted to summarize the evidence on the effect of ALA on BP. PubMed, SCOPUS, and Google Scholar databases were searched based on MESH term ("Thioctic acid" in combination with "Hypertension" and "Blood pressure") to identify related papers published up to December 2015. We summarized the results of the relevant studies in this review. In total, nine studies included in this review, seven parallel-designed trials and two crossover-designed trials. The results of parallel-designed studies are inconsistent. Five studies indicate no significant effects for ALA supplementation on BP, but two trials show effects on BP. Unlike parallel-designed trials, two crossover-designed trials have shown similar results and both report no effect for ALA on BP. Several studies investigated the effect of ALA on BP. Most of the papers show no significant effect for supplementation and the studies have shown that associations are limited. However, these findings are limited and there is a need for further and more accurate researches to be clarified.
尽管多项动物和人体研究探讨了α-硫辛酸（ALA）对血压（BP）的影响，但这些研究结果并不一致。本系统评价随机临床试验旨在总结ALA对血压影响的证据。基于医学主题词表（“硫辛酸”与“高血压”和“血压”组合）检索了PubMed、SCOPUS和谷歌学术数据库，以识别截至2015年12月发表的相关论文。我们在本评价中总结了相关研究的结果。本评价共纳入9项研究，7项平行设计试验和2项交叉设计试验。平行设计研究的结果不一致。5项研究表明补充ALA对血压无显著影响，但2项试验显示对血压有影响。与平行设计试验不同，2项交叉设计试验显示了相似的结果，且均报告ALA对血压无影响。多项研究探讨了ALA对血压的影响。大多数论文显示补充ALA无显著影响，且研究表明相关性有限。然而，这些发现是有限的，需要进一步进行更准确的研究以阐明。
