Baker I A, Eastham R, Elwood P C, Etherington M, O'Brien J R, Sweetnam P M
Br Heart J. 1982 May;47(5):490-4. doi: 10.1136/hrt.47.5.490.
In the Speedwell study set up to examine primarily the relation of plasma lipids and ischaemic heart disease in men aged 45 to 64 years drawn randomly from the practices of 16 general practitioners, various haemostatic factors which may contribute both to thrombogenesis and atherogenesis were measured. Fibrinogen measured nephelometrically and plasma viscosity were positively associated with the prevalence of ischaemic heart disease. Antithrombin III was negatively associated with the prevalence of ischaemic heart disease. These associations were statistically significant at the 1% level of probability. Fibrinogen measured by a clotting method and the heparin neutralising activity of platelet poor plasma had negative and positive associations with ischaemic heart disease, respectively, but neither association achieved statistical significance. Because of the interrelation of these variables and also age, a multiple logistic regression analysis was undertaken separately for the two measures of fibrinogen. The negative association of "clottable' fibrinogen and the positive association of plasma viscosity with the prevalence of ischaemic heart disease were confirmed and both were statistically significant at the 5% level of probability. Apart from age the independent association of the other variables with ischaemic heart disease did not achieve statistical significance. Fibrinogen measured by both methods had positive and statistically significant associations with serum total cholesterol, but no associations with serum total triglycerides, smoking, or alcohol consumption. "Clottable' fibrinogen had an inverse and statistically insignificant association with serum high density lipoprotein cholesterol. The observed associations support the concept of the involvement of some haemostatic factors in the aetiology of ischaemic heart disease, and these associations are now being examined more critically in a longitudinal study.
在一项名为“婆婆纳属植物”的研究中，主要对从16位全科医生的诊疗对象中随机抽取的45至64岁男性的血浆脂质与缺血性心脏病的关系进行了研究，同时还测量了各种可能导致血栓形成和动脉粥样硬化的止血因子。通过比浊法测量的纤维蛋白原和血浆粘度与缺血性心脏病的患病率呈正相关。抗凝血酶III与缺血性心脏病的患病率呈负相关。这些关联在1%的概率水平上具有统计学意义。通过凝血法测量的纤维蛋白原以及血小板缺乏血浆的肝素中和活性与缺血性心脏病分别呈负相关和正相关，但两者均未达到统计学意义。由于这些变量之间以及与年龄之间存在相互关系，因此对纤维蛋白原的两种测量方法分别进行了多元逻辑回归分析。“可凝”纤维蛋白原的负相关以及血浆粘度与缺血性心脏病患病率的正相关得到了证实，且两者在5%的概率水平上均具有统计学意义。除年龄外，其他变量与缺血性心脏病的独立关联未达到统计学意义。通过两种方法测量的纤维蛋白原与血清总胆固醇均呈正相关且具有统计学意义，但与血清总甘油三酯、吸烟或饮酒均无关联。“可凝”纤维蛋白原与血清高密度脂蛋白胆固醇呈负相关，但无统计学意义。观察到的这些关联支持了某些止血因子参与缺血性心脏病病因学的概念，目前正在一项纵向研究中对这些关联进行更严格的检验。
