Hollands P, Aboyeji D, Orcharton M
WideCells Institute of Stem Cell Technology (ISCT), University of Manchester Innovation Centre, Core Technology Facility, 46 Grafton Street, Manchester, M13 9NT.
Br Dent J. 2018 May 4. doi: 10.1038/sj.bdj.2018.348.
The mesenchymal stem cells (dental pulp stem cells; DPSC) found inside teeth represent a significant future source of stem cells for regenerative medicine procedures. This review describes the ontogeny of DPSC; the laboratory processing and collection of DPSC; the immuno-cytochemical characterisation of DPSC; the differentiation between adult DPSC and DPSC obtained from exfoliated deciduous teeth (SHED) and their potential use in regenerative medicine procedures in the future both in dental and general medical applications.
牙齿内部发现的间充质干细胞(牙髓干细胞;DPSC)是再生医学程序未来重要的干细胞来源。本综述描述了牙髓干细胞的个体发生;牙髓干细胞的实验室处理和采集;牙髓干细胞的免疫细胞化学特征;成人牙髓干细胞与脱落乳牙来源的干细胞(SHED)之间的区别,以及它们在未来牙科和普通医学应用的再生医学程序中的潜在用途。