Zhang Qing-Hua, Ding Yun, Bai Wen-Xin, Zhang Jian, Zhang Xiao-Qi, Ye Wen-Cai
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Ji'nan University, Guangzhou 510632, China.
Guangdong Technology Research Center for Advanced Chinese Medicine, College of Pharmacy, Ji'nan University, Guangzhou 510632, China.
Zhongguo Zhong Yao Za Zhi. 2018 Apr;43(7):1471-1475. doi: 10.19540/j.cnki.cjcmm.20180115.007.
To inverstigate the alkaloids from the twigs and leaves of Ervatamia pandacaqui, eleven known alkaloids were isolated by silica gel, Sephadex LH-20, and ODS column chromatography, as well as RP-HPLC. Their structures were elucidated by UV, IR, MS, and NMR spectral data as coronaridine (1), 3-oxocoronaridine (2), 19S-heyneanine (3), 19R-heyneanine (4), voacangine (5), 3-oxovoacangine (6), voacristine (7), 19-epi-voacristine (8), iso-voacangine (9), coronaridine 7-hydroxyindolenine (10), and voacangine 7-hydroxyindolenine (11). Compounds 1-11 were isolated from E. pandacaqui for the first time.
为研究药用狗牙花枝叶中的生物碱，通过硅胶柱色谱、葡聚糖凝胶LH - 20柱色谱、十八烷基硅烷键合硅胶柱色谱以及反相高效液相色谱法分离得到了11种已知生物碱。通过紫外光谱、红外光谱、质谱和核磁共振光谱数据确定它们的结构分别为冠狗牙花定碱（1）、3 - 氧代冠狗牙花定碱（2）、19S - 海牙亭碱（3）、19R - 海牙亭碱（4）、沃坎京碱（5）、3 - 氧代沃坎京碱（6）、沃克里斯廷碱（7）、19 - 表沃克里斯廷碱（8）、异沃坎京碱（9）、冠狗牙花定碱7 - 羟基吲哚宁（10）和沃坎京碱7 - 羟基吲哚宁（11）。化合物1 - 11首次从药用狗牙花中分离得到。
