Choi Youn-Hee, Kosaka Takayuki, Ojima Miki, Sekine Shinichi, Kokubo Yoshihiro, Watanabe Makoto, Miyamoto Yoshihiro, Ono Takahiro, Amano Atsuo
Department of Preventive Dentistry, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.
Department of Prosthodontics, Gerontology and Oral Rehabilitation, Osaka University Graduate School of Dentistry, Suita-Osaka, Japan.
BMC Oral Health. 2018 May 4;18(1):77. doi: 10.1186/s12903-018-0536-0.
The association of periodontal bacteria with lipid profile alteration remains largely unknown, although it has been suggested that chronic periodontitis increases the atherosclerotic risk. This cross-sectional study investigated the relationship between the prevalence and total burden of periodontal bacteria and serum lipid profile.
Saliva from enrolled participants was collected to detect 4 major periodontal bacteria (Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, and Prevotella intermedia) using Polymerase Chain Reaction method. High-density lipoprotein (HDL) cholesterol, triglycerides (TG), and low-density lipoprotein cholesterol were assessed using blood samples. We compared the averages of each lipid in association with the prevalence of each bacterial species, their burden (low, moderate, and high), and the combination of bacterial burden and periodontal status, defined as periodontitis, using the Community Periodontal Index, after adjustment for other potential confounding factors, by employing general linear models with least square means.
A total of 385 Japanese individuals (176 men, 209 women; mean age 69.2 years) were enrolled. The number of bacterial species and their co-existence with periodontitis were significantly related to a decrease in HDL (p for trend < 0.01) and increase in TG (p for trend = 0.04). The adjusted mean HDL levels (mg/dL) in individuals with low, moderate, and high levels of bacterial species were 66.1, 63.0, and 58.9, respectively, and those in the 6 groups defined by combination of the two factors were 67.9, 64.6, 64.3, 65.4, 61.5, and 54.7, respectively.
Periodontal bacterial burden is suggested to be independently involved in lowering serum HDL level. Our findings suggest that bacterial tests in a clinical setting could be a useful approach for predicting the risk of HDL metabolism dysregulation.
尽管有研究表明慢性牙周炎会增加动脉粥样硬化风险，但牙周细菌与血脂谱改变之间的关联仍不清楚。这项横断面研究调查了牙周细菌的患病率和总负荷与血清血脂谱之间的关系。
收集纳入研究的参与者的唾液，采用聚合酶链反应法检测4种主要牙周细菌（牙龈卟啉单胞菌、具核梭杆菌、福赛坦氏菌和中间普氏菌）。使用血液样本评估高密度脂蛋白（HDL）胆固醇、甘油三酯（TG）和低密度脂蛋白胆固醇。在调整其他潜在混杂因素后，我们采用具有最小二乘均值的一般线性模型，比较了每种脂质的平均值与每种细菌物种的患病率、它们的负荷（低、中、高）以及细菌负荷与牙周状况（定义为牙周炎）的组合之间的关系，牙周状况采用社区牙周指数进行评估。
共纳入385名日本个体（176名男性，209名女性；平均年龄69.2岁）。细菌物种的数量及其与牙周炎的共存与HDL降低（趋势p<0.01）和TG升高（趋势p=0.04）显著相关。细菌物种水平低、中、高的个体的调整后平均HDL水平（mg/dL）分别为66.1、63.0和58.9，由这两个因素组合定义的6组个体的调整后平均HDL水平分别为67.9、64.6、64.3、65.4、61.5和54.7。
牙周细菌负荷被认为独立参与降低血清HDL水平。我们的研究结果表明，临床环境中的细菌检测可能是预测HDL代谢失调风险的一种有用方法。
