一种基于网络药理学的方法来确定药对治疗类风湿性关节炎的协同机制。
A network pharmacology approach to determine the synergetic mechanisms of herb couple for treating rheumatic arthritis.
作者信息
Xu Xi-Xi, Bi Jian-Ping, Ping Li, Li Ping, Li Fei
机构信息
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, People's Republic of China.
Orthopedics Department, Shandong Provincial Traditional Chinese Medical Hospital, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People's Republic of China.
出版信息
Drug Des Devel Ther. 2018 Apr 24;12:967-979. doi: 10.2147/DDDT.S161904. eCollection 2018.
PURPOSE
The purpose of this study was to investigate the therapeutic mechanism(s) of Osbeck/ K.C. Ting ex H.T (CN).
METHODS
A network pharmacology approach integrating prediction of ingredients, target exploration, network construction, module partition and pathway analysis was used.
RESULTS
This approach successfully helped to identify 12 active ingredients of CN, interacting with 13 key targets (Akt1, STAT3, TNFsf13, TP53, EPHB2, IL-10, IL-6, TNF, MAPK8, IL-8, RELA, ROS1 and STAT4). Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis indicated that CN-regulated pathways were mainly classified into signal transduction and immune system.
CONCLUSION
The present work may help to illustrate the mechanism(s) of action of CN, and it may provide a better understanding of antirheumatic effects.
目的
本研究旨在探讨海风藤（Osbeck/ K.C. Ting ex H.T (CN)）的治疗机制。
方法
采用网络药理学方法，整合成分预测、靶点探索、网络构建、模块划分和通路分析。
结果
该方法成功鉴定出海风藤的12种活性成分，与13个关键靶点（Akt1、STAT3、TNFsf13、TP53、EPHB2、IL-10、IL-6、TNF、MAPK8、IL-8、RELA、ROS1和STAT4）相互作用。京都基因与基因组百科全书通路富集分析表明，海风藤调节的通路主要分为信号转导和免疫系统。
结论
本研究可能有助于阐明海风藤的作用机制，并有助于更好地理解其抗风湿作用。
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