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长链非编码 RNA FOXD2-AS1 通过与 microRNA-185-5p 的相互作用促进结直肠癌增殖。

Long non-coding RNA FOXD2-AS1 contributes to colorectal cancer proliferation through its interaction with microRNA-185-5p.

机构信息

Departments of Oncology, Henan Provincial People's Hospital, Zhengzhou, China.

Ear-Nose-Throat, Henan Provincial People's Hospital, Zhengzhou, China.

出版信息

Cancer Sci. 2018 Jul;109(7):2235-2242. doi: 10.1111/cas.13632. Epub 2018 Jun 13.

DOI:10.1111/cas.13632
PMID:29737580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6029818/
Abstract

Emerging evidence has indicated that long non-coding RNA plays an important role in carcinogenesis at the transcriptional and post-translational levels. The regulation of carcinogenesis-related effectors is potent in the determination of tumor initiation and progression. In the current study, FOXD2-AS1 was found to interact with microRNA (miR)-185-5p to modulate proliferation, migration, and invasion of colorectal cancer (CRC) cells. Interestingly, expression of cell division control 42 was significantly influenced by FOXD2-AS1 and miR-185-5p. In CRC patients, the expression level of FOXD2-AS1 in CRC tissue was closely associated with miR-185-5p and cell division control 42, and implicated in the overall survival rate. Therefore, our study suggests that long non-coding RNA FOXD2-AS1 plays a positive role in CRC and could be developed and used as a potential biomarker for the diagnosis and therapy of CRC. This will greatly improve the prevention and treatment of the third most common cancer worldwide.

摘要

新出现的证据表明，长非编码 RNA 在转录和翻译后水平的致癌作用中发挥重要作用。致癌相关效应物的调节在肿瘤发生和进展的决定中具有强大的作用。在本研究中，发现 FOXD2-AS1 与 microRNA（miR）-185-5p 相互作用，调节结直肠癌细胞（CRC）的增殖、迁移和侵袭。有趣的是，细胞分裂控制 42 的表达受到 FOXD2-AS1 和 miR-185-5p 的显著影响。在 CRC 患者中，CRC 组织中 FOXD2-AS1 的表达水平与 miR-185-5p 和细胞分裂控制 42 密切相关，并与总生存率有关。因此，我们的研究表明，长非编码 RNA FOXD2-AS1 在 CRC 中发挥积极作用，并可作为 CRC 诊断和治疗的潜在生物标志物进行开发和应用。这将极大地提高全球第三大常见癌症的防治水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83cf/6029818/e601ce127158/CAS-109-2235-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83cf/6029818/10ae38058eb3/CAS-109-2235-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83cf/6029818/83246551b853/CAS-109-2235-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83cf/6029818/3b937f44ff4c/CAS-109-2235-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83cf/6029818/3d80f8385167/CAS-109-2235-g004.jpg
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