Unger Katrin, Coclite Anna Maria
Institute of Solid State Physics, Graz University of Technology, 8010 Graz, Austria.
Pharmaceutics. 2020 Sep 22;12(9):904. doi: 10.3390/pharmaceutics12090904.
Encapsulation of pharmaceutical powders within thin functional polymer films is a powerful and versatile method to modify drug release properties. Conformal coating over the complete surface of the particle via chemical vapor deposition techniques is a challenging task due to the compromised gas-solid contact. In this study, an initiated chemical vapor deposition reactor was adapted with speakers and vibration of particles was achieved by playing AC/DC's song "Thunderstruck" to overcome the above-mentioned problem. To show the possibilities of this method, two types of powder of very different particle sizes were chosen, magnesium citrate (3-10 µm, cohesive powder) and aspirin (100-500 µm, good flowability), and coated with poly-ethylene-glycol-di-methacrylate. The release curve of coated magnesium citrate powder was retarded compared to uncoated powder. However, neither changing the thickness coating nor vibrating the powder during the deposition had influence on the release parameters, indicating, that cohesive powders cannot be coated conformally. The release of coated aspirin was as well retarded as compared to uncoated aspirin, especially in the case of the powder that vibrated during deposition. We attribute the enhancement of the retarded release to the formation of a conformal coating on the aspirin powder.
将药物粉末封装在功能性聚合物薄膜中是一种强大且通用的改变药物释放特性的方法。通过化学气相沉积技术在颗粒整个表面进行保形涂覆是一项具有挑战性的任务，因为气固接触会受到影响。在本研究中，对引发化学气相沉积反应器进行了改装，通过播放AC/DC乐队的歌曲《Thunderstruck》实现颗粒振动，以克服上述问题。为了展示这种方法的可能性，选择了两种粒径差异很大的粉末，柠檬酸镁（3 - 10微米，粘性粉末）和阿司匹林（100 - 500微米，流动性好），并用聚乙二醇二甲基丙烯酸酯进行涂覆。与未涂覆的粉末相比，涂覆的柠檬酸镁粉末的释放曲线延迟。然而，在沉积过程中改变涂层厚度或振动粉末对释放参数均无影响，这表明粘性粉末无法进行保形涂覆。与未涂覆的阿司匹林相比，涂覆的阿司匹林的释放也有延迟，特别是在沉积过程中振动的粉末的情况下。我们将延迟释放的增强归因于阿司匹林粉末上形成了保形涂层。
