The HLA Research Group, Brain Sciences Center (11B), Department of Veterans Affairs Health Care System, Minneapolis VAHCS, One Veterans Drive, Minneapolis, MN, 55417, USA.
Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Sci Rep. 2022 May 4;12(1):7235. doi: 10.1038/s41598-022-11366-7.
Human leukocyte antigen (HLA) genes have been implicated in cancer risk and shared heritability of different types of cancer. In this immunogenetic epidemiological study we first computed a Cancer-HLA profile for 30 cancer types characterized by the correlation between the prevalence of each cancer and the population frequency of 127 HLA alleles, and then used multidimensional scaling to evaluate the possible clustering of those Cancer-HLA associations. The results indicated the presence of three clusters, broadly reflecting digestive-skin-cervical cancers, reproductive and endocrine systems cancers, and brain and androgen-associated cancers. The clustering of cancer types documented here is discussed in terms of mechanisms underlying shared Cancer-HLA associations.
人类白细胞抗原 (HLA) 基因与癌症风险和不同类型癌症的遗传共享有关。在这项免疫遗传学流行病学研究中，我们首先计算了 30 种癌症的癌症-HLA 图谱，其特征是每种癌症的流行率与 127 个 HLA 等位基因的人群频率之间的相关性，然后使用多维标度来评估这些癌症-HLA 关联的可能聚类。结果表明存在三个聚类，大致反映了消化-皮肤-宫颈癌症、生殖和内分泌系统癌症以及脑和雄激素相关癌症。本文讨论了所记录的癌症类型聚类，涉及共享癌症-HLA 关联的潜在机制。
