• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人体昼夜节律系统的夹带及光疗法恢复的数值研究。

Numerical study of entrainment of the human circadian system and recovery by light treatment.

作者信息

Kim Soon Ho, Goh Segun, Han Kyungreem, Kim Jong Won, Choi MooYoung

机构信息

Department of Physics and Center for Theoretical Physics, Seoul National University, Gwanak-ro 1, Seoul, 08826, Korea.

Institut für Theoretische Physik II - Soft Matter, Heinrich-Heine- Universität Düsseldorf, Düsseldorf, D-40225, Germany.

出版信息

Theor Biol Med Model. 2018 May 9;15(1):5. doi: 10.1186/s12976-018-0077-x.

DOI:10.1186/s12976-018-0077-x
PMID:29743086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5944165/
Abstract

BACKGROUND

While the effects of light as a zeitgeber are well known, the way the effects are modulated by features of the sleep-wake system still remains to be studied in detail.

METHODS

A mathematical model for disturbance and recovery of the human circadian system is presented. The model combines a circadian oscillator and a sleep-wake switch that includes the effects of orexin. By means of simulations, we characterize the period-locking zone of the model, where a stable 24-hour circadian rhythm exists, and the occurrence of circadian disruption due to both insufficient light and imbalance in orexin. We also investigate how daily bright light treatments of short duration can recover the normal circadian rhythm.

RESULTS

It is found that the system exhibits continuous phase advance/delay at lower/higher orexin levels. Bright light treatment simulations disclose two optimal time windows, corresponding to morning and evening light treatments. Among the two, the morning light treatment is found effective in a wider range of parameter values, with shorter recovery time.

CONCLUSIONS

This approach offers a systematic way to determine the conditions under which circadian disruption occurs, and to evaluate the effects of light treatment. In particular, it could potentially offer a way to optimize light treatments for patients with circadian disruption, e.g., sleep and mood disorders, in clinical settings.

摘要

背景

虽然光作为一种授时因子的作用已广为人知，但睡眠-觉醒系统的特征对其作用的调节方式仍有待详细研究。

方法

提出了一种人类昼夜节律系统干扰与恢复的数学模型。该模型结合了一个昼夜节律振荡器和一个包含食欲素作用的睡眠-觉醒开关。通过模拟，我们刻画了模型的锁相区，即存在稳定的24小时昼夜节律的区域，以及由于光照不足和食欲素失衡导致的昼夜节律紊乱的发生情况。我们还研究了短时间的每日强光治疗如何恢复正常的昼夜节律。

结果

发现该系统在较低/较高食欲素水平下表现出连续的相位提前/延迟。强光治疗模拟揭示了两个最佳时间窗口，分别对应早晨和傍晚的光照治疗。其中，早晨光照治疗在更广泛的参数值范围内有效，恢复时间更短。

结论

这种方法提供了一种系统的方式来确定昼夜节律紊乱发生的条件，并评估光照治疗的效果。特别是，它有可能为临床环境中昼夜节律紊乱患者（如睡眠和情绪障碍患者）优化光照治疗提供一种方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9855/5944165/5c0fb4a50ddc/12976_2018_77_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9855/5944165/d254faf728b6/12976_2018_77_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9855/5944165/a4f3fc3cbbef/12976_2018_77_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9855/5944165/23ad404712e7/12976_2018_77_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9855/5944165/9de265deed54/12976_2018_77_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9855/5944165/6aa319badcc7/12976_2018_77_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9855/5944165/5c0fb4a50ddc/12976_2018_77_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9855/5944165/d254faf728b6/12976_2018_77_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9855/5944165/a4f3fc3cbbef/12976_2018_77_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9855/5944165/23ad404712e7/12976_2018_77_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9855/5944165/9de265deed54/12976_2018_77_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9855/5944165/6aa319badcc7/12976_2018_77_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9855/5944165/5c0fb4a50ddc/12976_2018_77_Fig6_HTML.jpg

相似文献

1
Numerical study of entrainment of the human circadian system and recovery by light treatment.人体昼夜节律系统的夹带及光疗法恢复的数值研究。
Theor Biol Med Model. 2018 May 9;15(1):5. doi: 10.1186/s12976-018-0077-x.
2
Treating chronobiological components of chronic insomnia.治疗慢性失眠的时间生物学成分。
Sleep Med. 2007 Sep;8(6):637-44. doi: 10.1016/j.sleep.2006.10.003. Epub 2007 Mar 26.
3
Exploring sleepiness and entrainment on permanent shift schedules in a physiologically based model.探讨基于生理学的模型中永久性轮班制下的困倦和同步性。
J Biol Rhythms. 2012 Feb;27(1):91-102. doi: 10.1177/0748730411419934.
4
Preflight adjustment to eastward travel: 3 days of advancing sleep with and without morning bright light.向东旅行的飞行前调整：提前3天在有或没有早晨强光照射的情况下提前入睡。
J Biol Rhythms. 2003 Aug;18(4):318-28. doi: 10.1177/0748730403253585.
5
Optimization of light exposure and sleep schedule for circadian rhythm entrainment.优化光照和睡眠时间表以适应昼夜节律。
PLoS One. 2021 Jun 8;16(6):e0251478. doi: 10.1371/journal.pone.0251478. eCollection 2021.
6
Working under daylight intensity lamp: an occupational risk for developing circadian rhythm sleep disorder?在日光强度灯下工作：会增加患昼夜节律性睡眠障碍的职业风险吗？
Chronobiol Int. 2005;22(3):597-605. doi: 10.1081/CBI-200062422.
7
[Daily phase adjustment of human sleep-wake cycle].[人类睡眠-觉醒周期的每日相位调整]
Nihon Rinsho. 2009 Aug;67(8):1475-82.
8
[Non-photic entrainment of human circadian clock--effects of forced sleep-wake schedule on the circadian rhythm in plasma melatonin].[人类生物钟的非光驱动同步——强制睡眠-清醒时间表对血浆褪黑素昼夜节律的影响]
Hokkaido Igaku Zasshi. 1996 May;71(3):403-22.
9
Effect of timed bright light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease.定时强光疗法对机构照料的阿尔茨海默病患者休息 - 活动紊乱的影响。
Int J Geriatr Psychiatry. 2005 Aug;20(8):738-43. doi: 10.1002/gps.1352.
10
[Circadian rhythm sleep-wake disorder (circadian rhythm sleep disorder)].昼夜节律性睡眠-觉醒障碍（昼夜节律性睡眠障碍）
Nihon Rinsho. 2015 Jun;73(6):942-8.

引用本文的文献

1
Desynchronosis: Types, Main Mechanisms, Role in the Pathogenesis of Epilepsy and Other Diseases: A Literature Review.睡眠失调：类型、主要机制、在癫痫及其他疾病发病机制中的作用：文献综述
Life (Basel). 2022 Aug 11;12(8):1218. doi: 10.3390/life12081218.

本文引用的文献

1
Wake-sleep transition as a noisy bifurcation.清醒-睡眠转换作为一种噪声分岔。
Phys Rev E. 2016 Aug;94(2-1):022412. doi: 10.1103/PhysRevE.94.022412. Epub 2016 Aug 15.
2
A physiologically based model of orexinergic stabilization of sleep and wake.一种基于生理学的食欲素能睡眠与觉醒稳定模型。
PLoS One. 2014 Mar 20;9(3):e91982. doi: 10.1371/journal.pone.0091982. eCollection 2014.
3
Physiologically-based modeling of sleep-wake regulatory networks.基于生理学的睡眠-觉醒调节网络建模。
Math Biosci. 2014 Apr;250:54-68. doi: 10.1016/j.mbs.2014.01.012. Epub 2014 Feb 11.
4
Mammalian rest/activity patterns explained by physiologically based modeling.基于生理学的建模解释哺乳动物的休息/活动模式。
PLoS Comput Biol. 2013;9(9):e1003213. doi: 10.1371/journal.pcbi.1003213. Epub 2013 Sep 5.
5
Adaptation to shift work: physiologically based modeling of the effects of lighting and shifts' start time.适应轮班工作：光照和轮班开始时间影响的基于生理学的建模。
PLoS One. 2013;8(1):e53379. doi: 10.1371/journal.pone.0053379. Epub 2013 Jan 4.
6
Central and peripheral circadian clocks in mammals.哺乳动物的中枢和外周生物钟。
Annu Rev Neurosci. 2012;35:445-62. doi: 10.1146/annurev-neuro-060909-153128. Epub 2012 Apr 5.
7
Incorporation of caffeine into a quantitative model of fatigue and sleep.将咖啡因纳入疲劳和睡眠的定量模型中。
J Theor Biol. 2011 Mar 21;273(1):44-54. doi: 10.1016/j.jtbi.2010.12.018. Epub 2010 Dec 19.
8
Circadian rhythms and sleep in bipolar disorder.双相情感障碍中的昼夜节律和睡眠。
Bipolar Disord. 2010 Aug;12(5):459-72. doi: 10.1111/j.1399-5618.2010.00843.x.
9
Quantitative physiologically based modeling of subjective fatigue during sleep deprivation.睡眠剥夺期间主观疲劳的定量生理基础建模。
J Theor Biol. 2010 May 21;264(2):407-19. doi: 10.1016/j.jtbi.2010.02.028. Epub 2010 Feb 19.
10
A mathematical model of the sleep/wake cycle.睡眠/清醒周期的数学模型。
J Math Biol. 2010 May;60(5):615-44. doi: 10.1007/s00285-009-0276-5. Epub 2009 Jun 26.