膳食脂肪摄入与 Cav-1 rs3807992 多态性在超重和肥胖女性脂肪分布中的相互作用：一项横断面研究。
The interactions between dietary fats intake and Caveolin 1 rs 3807992 polymorphism with fat distribution in overweight and obese women: a cross-sectional study.
机构信息
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box, 14155-6117, Tehran, Iran.
出版信息
BMC Med Genomics. 2021 Nov 9;14(1):265. doi: 10.1186/s12920-021-01114-7.
BACKGROUND
It has been reported that dietary fats and genetic factors in individuals are associated with the pattern of fat distribution. This study aimed to evaluate the interaction between dietary fats intake and Caveolin1 (CAV-1) rs 3807s992 polymorphism with fat distribution in overweight and obese women.
METHODS
A total of 221 participants were included in the current cross-sectional study. Body composition, biochemical parameters were evaluated by body composition analyzer and Pars Azmoon kits and genotypes determination was performed by PCR-RFLP, dietary fats were measured using a validated semi-quantitative food frequency questionnaire (FAQ).
RESULTS
The frequency of GG, AA and AG genotypes were 53.1, 24.6, and 22.3%, respectively, and the mean intake of total dietary fat intake was 97.47 ± 36.87 g. There was positive significant interaction between total fat intake and AA genotype on visceral fat level (p = 0.001), trunk fat (p = 0.01) and waist circumference (p = 0.05), positive significant interaction between total fat intake and AG genotype on the waist to hip ratio (WHR) (p = 0.02) and visceral fat level (p = 0.05), positive borderline significant interaction between saturated fatty acid and AA genotype on the trunk fat (p = 0.06), and between trans-fatty acids and AG genotype on WHR (p = 0.04), visceral fat level (p = 0.01), and between monounsaturated fatty acid and AG genotype on WHR (p = 0.04), and a borderline interaction between polyunsaturated fatty acid and AA genotypes on visceral fat level (p = 0.06), negative significant interaction between AG genotypes and linolenic acid on WHR (p = 0.04), borderline significant interaction between ALA and AG genotype on WHR (p = 0.06).
CONCLUSIONS
Our findings showed that CAV-1 rs 3807992 polymorphism and dietary fats were associated with fat distributions in individuals.
背景
据报道，个体的膳食脂肪和遗传因素与脂肪分布模式有关。本研究旨在评估膳食脂肪摄入与 CAV-1 rs3807992 多态性与超重和肥胖女性脂肪分布之间的相互作用。
方法
本横断面研究共纳入 221 名参与者。通过人体成分分析仪和 Pars Azmoon 试剂盒评估身体成分和生化参数，通过 PCR-RFLP 进行基因型测定，使用经过验证的半定量食物频率问卷（FAQ）测量膳食脂肪。
结果
GG、AA 和 AG 基因型的频率分别为 53.1%、24.6%和 22.3%，总膳食脂肪摄入量的平均值为 97.47±36.87g。总脂肪摄入量与 AA 基因型之间存在显著正交互作用，表现在内脏脂肪水平（p=0.001）、躯干脂肪（p=0.01）和腰围（p=0.05），总脂肪摄入量与 AG 基因型之间存在显著正交互作用，表现在腰臀比（WHR）（p=0.02）和内脏脂肪水平（p=0.05），饱和脂肪酸与 AA 基因型之间存在显著正交互作用，表现在躯干脂肪（p=0.06），反式脂肪酸与 AG 基因型之间存在显著正交互作用，表现在 WHR（p=0.04）、内脏脂肪水平（p=0.01）和单不饱和脂肪酸与 AG 基因型之间存在显著正交互作用，表现在 WHR（p=0.04），多不饱和脂肪酸与 AA 基因型之间存在边缘交互作用，表现在内脏脂肪水平（p=0.06），AG 基因型与亚麻酸之间存在显著负交互作用，表现在 WHR（p=0.04），ALA 与 AG 基因型之间存在边缘交互作用，表现在 WHR（p=0.06）。
结论
本研究结果表明，CAV-1 rs3807992 多态性与膳食脂肪与个体的脂肪分布有关。
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