Department of Ophthalmology, Semmelweis University, Budapest, Hungary.
J Glaucoma. 2018 Aug;27(8):e137-e139. doi: 10.1097/IJG.0000000000000990.
To investigate the usefulness of removing the large vessel-related information from peripapillary optical coherence tomography angiography progression analysis. Peripapillary vessel density (VD) image series which had shown no progression with an earlier software version that did not separate capillary and large vessel-related effects were reevaluated for selective peripapillary capillary VD progression.
Prospective retinal nerve fiber layer thickness and peripapillary VD measurements were made using the Angiovue/RTvue-XR OCT on 1 eye of 9 normal, 20 under treatment ocular hypertensive, and 24 under treatment open-angle glaucoma patients at 6-month intervals for 2 years (5 visits). In the current investigation the previously analyzed images were reanalyzed. Linear regression analysis for capillary VD progression in the radial peripapillary capillaries layer of the superior and inferior peripapillary hemifields, respectively, was made using the instrument's new software (version 2017.1, Phase 7 update).
A statistically significant negative capillary VD slope was found in 4 glaucoma eyes. Two eyes progressed in both hemifields, and 2 eyes in 1 hemifield. The rate of statistically significant progression ranged between -1.3% and-3.2% per year. In 2 eyes the spatially corresponding hemifield retinal nerve fiber layer thickness progression was also significant (-1.4 μm/y and -1.8 μm/y). No normal and ocular hypertensive eyes showed significant capillary VD progression.
In this 2-year prospective study no eye showed progression for peripapillary VD when all vessel-related information was used. In contrast, software-provided removal of the large retinal vessels-related information resulted in detection of significant capillary VD progression in 17% of the glaucoma eyes.
研究从视盘周围光学相干断层扫描血管造影进展分析中去除大血管相关信息的有用性。对先前使用不分离毛细血管和大血管相关效应的较早软件版本显示无进展的视盘周围血管密度（VD）图像系列进行重新评估，以评估选择性视盘周围毛细血管 VD 进展。
对 9 例正常、20 例治疗性高眼压和 24 例治疗性开角型青光眼患者的 1 只眼，使用 Angiovue/RTvue-XR OCT，在 2 年内每 6 个月进行视网膜神经纤维层厚度和视盘周围 VD 测量（共 5 次访视）。在本研究中，对先前分析的图像进行了重新分析。使用仪器的新软件（版本 2017.1，第 7 阶段更新），对分别位于上下视盘旁毛细血管层的视盘旁毛细血管进展进行径向线性回归分析。
在 4 只青光眼眼中发现了统计学上显著的负向毛细血管 VD 斜率。2 只眼在两个半视野中进展，2 只眼在一个半视野中进展。统计学上显著进展的速度范围为每年-1.3%至-3.2%。在 2 只眼中，空间上相应的半视野视网膜神经纤维层厚度进展也很显著（-1.4μm/y 和-1.8μm/y）。没有正常眼和高眼压眼显示出显著的毛细血管 VD 进展。
在这项为期 2 年的前瞻性研究中，当使用所有血管相关信息时，没有眼显示视盘周围 VD 进展。相反，软件提供的去除大视网膜血管相关信息导致在 17%的青光眼眼中检测到显著的毛细血管 VD 进展。
