Holló Gábor
Department of Ophthalmology, Semmelweis University, Budapest, Hungary.
Ann Transl Med. 2020 Sep;8(18):1203. doi: 10.21037/atm.2020.03.187.
Glaucoma, a well-defined group of progressive optic neuropathies is one of the leading causes of irreversible blindness worldwide. In order to stop or slow down the progression of glaucomatous vision deterioration, intraocular pressure reduction by medical, laser or surgical treatment is needed. To ensure that treatment is efficient and tailored to the actual needs both cross sectional evaluation of disease severity and measurement of rate of progression are essential. Currently staging and progression are investigated with visual field and retinal thickness measurements. Perimetry, however, is influenced by several biological factors which are not related to glaucoma, and the use of retinal thinning is limited by floor effect. Therefore, clinical application of optical retinal coherence tomography angiography, a new and rapidly developing non-invasive measurement of the capillary perfusion in the various retinal layers, respectively, is now in the focus of clinical glaucoma research. This comprehensive review summarizes the current knowledge on one of the most important research areas in optical coherence tomography angiography in glaucoma, the relationship between retinal capillary perfusion and the spatially corresponding visual field threshold sensitivity.
青光眼是一组明确的进行性视神经病变，是全球不可逆性失明的主要原因之一。为了阻止或减缓青光眼性视力恶化的进展，需要通过药物、激光或手术治疗降低眼压。为确保治疗有效且符合实际需求，对疾病严重程度进行横断面评估以及测量进展速度至关重要。目前，通过视野和视网膜厚度测量来研究分期和进展情况。然而，视野检查受多种与青光眼无关的生物学因素影响，而视网膜变薄的应用受到下限效应的限制。因此，光学视网膜相干断层扫描血管造影术作为一种新的、快速发展的分别对视网膜各层毛细血管灌注进行无创测量的技术，其临床应用目前已成为青光眼临床研究的重点。这篇综述总结了青光眼光学相干断层扫描血管造影术最重要研究领域之一的当前知识，即视网膜毛细血管灌注与空间上相应的视野阈值敏感性之间的关系。
