Pic Emilie, Burgain Anaïs, Sellam Adnane
Infectious Diseases Research Centre-CRI, CHU de Québec Research Center (CHUQ), Université Laval, Quebec City, QC, Canada.
Department of Microbiology, Infectious Disease and Immunology, Faculty of Medicine, Université Laval, Quebec City, QC, Canada.
Med Mycol. 2019 Apr 1;57(3):387-390. doi: 10.1093/mmy/myy027.
Current antifungal drugs suffer from limitations including toxicity, adverse interactions with other commonly prescribed drugs, and the emergence of resistant strains. Here, we repurposed the anthelmintic oxyclozanide as a potent antifungal agent against both sensitive and resistant clinical isolates of Candida albicans, as well as other human opportunistic fungi. Antifungal activity of oxyclozanide was enhanced when C. albicans grew in nonfermentable carbon sources. Our data support a mechanism of action where oxyclozanide uncoupled the mitochondrial electron transport from oxidative phosphorylation and perturbed the mitochondrial membrane potential.
目前的抗真菌药物存在局限性，包括毒性、与其他常用处方药的不良相互作用以及耐药菌株的出现。在此，我们将驱虫药奥昔氯唑胺重新用作一种有效的抗真菌剂，用于对抗白色念珠菌的敏感和耐药临床分离株以及其他人类机会性真菌。当白色念珠菌在不可发酵碳源中生长时，奥昔氯唑胺的抗真菌活性增强。我们的数据支持一种作用机制，即奥昔氯唑胺使线粒体电子传递与氧化磷酸化解偶联，并扰乱线粒体膜电位。
