Department of Dermatopathology Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Department of Dermatology Faculty of Medicine University of Debrecen, Hungary.
J Dtsch Dermatol Ges. 2018 Jun;16(6):685-692. doi: 10.1111/ddg.13529. Epub 2018 May 15.
Herpes simplex virus (HSV)-1 and -2 infections are highly prevalent worldwide. HSV infection during pregnancy can result in neonatal herpes infection, which is characterized by lifelong infection with periods of latency and reactivation. HSV can be acquired by an infant during one of three periods: in utero (5 %), peripartum (85 %), or postnatal (10 %). Neonatal HSV is a rare but significant infection that may be associated with severe morbidity and mortality, especially if there is dissemination or central nervous system involvement. Diagnostic and therapeutic advances have led to a reduction in mortality and, to a lesser extent, improvement of neurodevelopmental outcomes, but further developments are still needed. It is essential to improve the clinician's ability to identify infants who are at increased risk of HSV infection and to prevent mother-to-child transmission. The development of novel antiviral agents with higher efficacy is a worthwhile aim for the future.
单纯疱疹病毒 1 型和 2 型（HSV-1 和 HSV-2）感染在全球范围内非常普遍。孕妇感染 HSV 可导致新生儿疱疹感染，其特征为终身潜伏和再激活感染。婴儿可在以下三个时期中的一个时期感染 HSV：宫内（5%）、围产期（85%）或产后（10%）。新生儿 HSV 是一种罕见但严重的感染，可能与严重的发病率和死亡率相关，尤其是存在播散或中枢神经系统受累的情况下。诊断和治疗的进步导致死亡率降低，在一定程度上也改善了神经发育结局，但仍需要进一步发展。提高临床医生识别存在 HSV 感染风险增加的婴儿的能力并预防母婴传播至关重要。开发具有更高疗效的新型抗病毒药物是未来值得追求的目标。
